RARS

Entrez Summary: N/A
UniProt Summary: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684). {ECO:0000269|PubMed:17443684, ECO:0000269|PubMed:25288775}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	-2.3
CCCP 0.1μM R00 exp10	-1.91
Ribavirin 10μM R01 exp52	-1.71
Oligomycin-A 20μM R00 exp26	1.76
YM155 0.001μM R08 exp432	1.78
Adefovir 20μM R07 exp332	1.79
Quinacrine 2.5μM R03 exp146	1.8
Pyronaridine 1μM R06 exp295	1.84
UM131593 0.2μM R03 exp106	1.88
OICR-9429 10μM R03 exp142	2.04
BI-6727 0.0125μM R03 exp97	2.16
Nicotinamide Riboside 100μM R03 exp139	2.25
GSK-LSD1 10μM R03 exp123	2.37
L-74142 5μM R03 exp131	2.57
SGC0649 7μM R03 exp150	2.8

Global Fraction of Cell Lines Where Essential: 21/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	2/26
breast	2/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	3/75
lymphocyte	0/16
ovary	1/26
pancreas	1/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution