SLC7A1
Gene Information
- Official Symbol: SLC7A1
- Official Name: solute carrier family 7 member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6541
- UniProt: P30825
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. {ECO:0000269|PubMed:10485994}.
Pfam Domains GO Terms
Pfam Domains
| AA permease |
GO Terms
| L-arginine import across plasma membrane |
| arginine transmembrane transporter activity |
| L-lysine transmembrane transporter activity |
| L-ornithine transmembrane transporter activity |
| L-arginine transmembrane transport |
| L-lysine transmembrane transport |
| L-lysine transport |
| arginine transmembrane transport |
| L-arginine transport |
| L-ornithine transmembrane transport |
| ornithine transport |
| arginine transport |
| basic amino acid transmembrane transport |
| basic amino acid transport |
| amino acid import across plasma membrane |
| amino acid import |
| amino acid transmembrane transporter activity |
| L-alpha-amino acid transmembrane transport |
| L-amino acid transport |
| drug transmembrane transport |
| amino acid transmembrane transport |
| import across plasma membrane |
| amino acid transport |
| carboxylic acid transmembrane transport |
| organic acid transmembrane transport |
| drug transport |
| anion transmembrane transport |
| organic acid transport |
| carboxylic acid transport |
| organic anion transport |
| anion transport |
| protein-containing complex |
| cation transmembrane transport |
| import into cell |
| cation transport |
| ion transmembrane transport |
| response to drug |
| transmembrane transport |
| ion transport |
| integral component of plasma membrane |
| nitrogen compound transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 14/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 3/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 2/16 |
| ovary | 0/26 |
| pancreas | 2/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 524
- Expression level (log2 read counts): 8.76
Expression Distribution
SLC7A1 Expression in NALM6 Cells: 8.76
