UMPS

Entrez Summary: This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Torin1 0.08μM R02 exp82	-3.24
FK-506 30μM R07 exp359	-2.64
Erlotinib 10μM R05 exp216	-2.48
Radicicol 0.16μM R05 exp242	-2.22
GSK-J4 1-1.25μM to day4 R07 exp363	-2.15
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-2.11
JQ1 0.01μM R03 exp130	-2.1
Epigallocatechin gallate 20μM R05 exp230	-2.04
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.98
HMS-I1 10μM R06 exp256	-1.92
LJH685 5μM R02 exp73	-1.91
5-Azacytidine 2μM R07 exp330	-1.89
FK-506 5μM R07 exp358	-1.89
Dimethyl-Sulfoxide 1pc R03 exp120	-1.84
Salubrinal 20μM R07 exp399	-1.82
Tunicamycin 0.04μM R07 exp418	-1.82
MK-1775 0.32μM R02 exp75	-1.8
Bisphenol A 100μM R06 exp269	-1.76
Alda-1 10μM R06 exp262	-1.75
ABT-702 5μM R07 exp318	-1.7
Nocodazole 0.2μM R02 exp64	1.7
Apcin 25μM plus proTAME 2μM R04 exp177	1.72
Nicotinate 1000μM R03 exp140	1.79
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.81
S-trityl-L-cysteine 0.5μM R05 exp243	1.85
5-Fluorouracil 2μM R00 exp1	1.95
GSK461364A 0.005μM R03 exp125	2
Myriocin 25μM R06 exp293	2
A-395N 10μM R05 exp219	2.23
Dinaciclib 0.007μM R07 exp355	3.37

Global Fraction of Cell Lines Where Essential: 91/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	14/28
bone	2/26
breast	8/33
central nervous system	1/56
cervix	0/4
colorectal	2/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	4/21
liver	1/20
lung	5/75
lymphocyte	5/16
ovary	0/26
pancreas	5/24
peripheral nervous system	1/16
plasma cell	4/15
prostate	0/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	1/5

Expression Distribution