Table of Contents

Quinacrine 2.5μM R03 exp146

Mechanism of Action

Intercalates into DNA and RNA, interferes with transcription and translation

Technical Notes

Protein References

  • PubChem Name: Quinacrine dihydrochloride
  • Synonyms: Mepacrine (dihydrochloride); SN-390 (dihydrochloride)
  • CAS #: 69-05-6
  • PubChem CID: 6239
  • IUPAC: 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine;dihydrochloride
  • INCHI Name: InChI=1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
  • INCHI Key: UDKVBVICMUEIKS-UHFFFAOYSA-N
  • Molecular Weight: 472.9
  • Canonical SMILES: CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC.Cl.Cl
  • Isomeric SMILES: N/A
  • Molecular Formula: C23H32Cl3N3O

Protein Supplier

  • Supplier Name: Sigma-Aldrich
  • Catalog #: Q3251
  • Lot #: BCBN9703V

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C23H30ClN3O 400.21502; found 400.21557

Dose Response Curve

  • Platform ID: QUINACRINE
  • Min: 0.8074; Max: 98.8966





IC Concentration (µM)
IC10 N/A
IC20 1.9289
IC30 2.3830
IC40 2.8339
IC50 3.3224
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
0/1ScoresViewViewViewViewView