CyclicAMP 200μM R08 exp475

Second messenger, activates PKA, ion channels, cyclic nucleotide-binding proteins

PubChem Name: Cyclic AMP
Synonyms: Adenosine 3',5'-cyclophosphate; Cyclic 3',5'-monophosphate adenosine; Cyclic AMP; Adenosine 3',5'-cyclophosphate; Cyclic 3',5'-monophosphate adenosine; Cyclic AMP
CAS #: 60-92-4
PubChem CID: 6076
IUPAC: (4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
INCHI Name: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
INCHI Key: IVOMOUWHDPKRLL-KQYNXXCUSA-N
Molecular Weight: 329.21
Canonical SMILES: C1C2C(C(C(O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(O1)O
Isomeric SMILES: C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(O1)O
Molecular Formula: C10H12N5O6P

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
2/5	Scores	View	View	View	View	View

GO Term	Fold Change	Genes
ribonucleoside monophosphate metabolic process	42.32	AMPD2,UCK2,NT5C2,DPYD

GO Term	Fold Change	Genes
de novo IMP biosynthetic process	331.38	ATIC,GART,PFAS
de novo XMP biosynthetic process	276.15	ATIC,GART,PFAS
XMP biosynthetic process	276.15	ATIC,GART,PFAS
de novo AMP biosynthetic process	236.70	ATIC,GART,PFAS
hydroxymethyl-, formyl- and related transferase activity	236.70	ATIC,SHMT2,GART
AMP biosynthetic process	230.12	ADK,ATIC,NUDT2,GART,PFAS
GMP biosynthetic process	169.94	ADK,ATIC,GART,PFAS
IMP biosynthetic process	165.69	ATIC,GART,PFAS
purine ribonucleoside monophosphate biosynthetic process	153.42	ADK,ATIC,NUDT2,GART,PFAS
purine nucleoside monophosphate biosynthetic process	110.46	ADK,ATIC,NUDT2,PFAS
AMP metabolic process	100.42	ADK,NUDT2,GART,PFAS
ribonucleoside monophosphate biosynthetic process	83.68	ADK,ATIC,NUDT2,GART,PFAS
nucleoside monophosphate biosynthetic process	69.04	ADK,ATIC,NUDT2,GART,PFAS
purine ribonucleoside monophosphate metabolic process	69.04	ADK,ATIC,NUDT2,GART,PFAS
purine nucleoside monophosphate metabolic process	65.75	ADK,ATIC,NUDT2,GART,PFAS
ribonucleoside monophosphate metabolic process	47.61	ADK,ATIC,NUDT2,GART,PFAS
nucleoside monophosphate metabolic process	36.82	ADK,ATIC,NUDT2,GART,PFAS
purine-containing compound metabolic process	10.40	ADK,ATIC,G6PD,NUDT2,MDH2,SHMT2,GART,PFAS
nucleobase-containing small molecule metabolic process	9.33	ADK,ATIC,G6PD,NUDT2,RRM2,MDH2,SHMT2,GART,PFAS