C18orf8

Entrez Summary: This gene encodes a colon cancer associated protein. [provided by RefSeq, Jan 2013].
UniProt Summary: Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162). {ECO:0000269|PubMed:29038162}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Clomiphene 4.4μM R02 exp68	-2.91
BH1 1μM R04 exp169	-2.36
NN-Dimethylsphingosine 2.5μM R08 exp508	-2.24
UM0125461 0.74μM R02 exp84	-2.21
TRAIL 50ng/ml R00 exp36	-2.06
LJH685 5μM R02 exp73	-1.87
IU1-47 25μM R04 exp182	-1.77
Vemurafenib 6.6μM R02 exp89	-1.76
CHIR-124 0.04μM R06 exp272	-1.73
EPZ-5676 30μM R05 exp233	1.71
SB743921 0.001μM R05 exp244	1.74
Wiskostatin 3μM R07 exp422	1.77
Momordin-Ic 10μM R08 exp506	1.88
Bafilomycin-A1 0.009μM R08 exp454	2.09
Tenofovir 10μM R07 exp405	2.09
Lenalidomide 20μM R07 exp375	2.15
Betulinic acid 10 to 15μM on day4 R05 exp222	2.65

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Mon1-Ccz1 complex
late endosome membrane
autophagy
process utilizing autophagic mechanism
lysosomal membrane
regulation of autophagy
regulation of cellular catabolic process
regulation of catabolic process
cellular catabolic process