DPM1

Entrez Summary: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015].
UniProt Summary: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins; catalytic subunit of the dolichol- phosphate mannose (DPM) synthase complex.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol S 100μM R08 exp458	-2.15
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.13
Golgicide-A 4μM R03 exp122	-2.08
Apcin 50 to 100μM on day4 R04 exp176	-1.72
SGC0649 7μM R03 exp150	-1.7
Monensin 0.3μM R08 exp507	1.74
Trimetrexate 0.03μM R08 exp535	1.75
GSK626616 14μM R08 exp485	1.84
HMS-I1 10μM R06 exp256	1.86
Hippuristanol 0.12μM R08 exp488	1.87
CB-5083 0.4μM R08 exp468	1.91
Rapamycin 0.001μM R08 exp429	1.91
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.92
YM155 0.001μM R08 exp432	2.04
Mitomycin-C 0.06μM R08 exp503	2.18
LJH685 50μM R08 exp433	2.27
CoCl2 18μM R07 exp346	2.31
Staurosporine 0.02μM R08 exp524	2.4
Arsenate 40μM R06 exp264	3.23

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	2/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	4/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dolichyl-phosphate beta-D-mannosyltransferase activity
dolichol-phosphate-mannose synthase complex
dolichol metabolic process
polyprenol metabolic process
dolichyl-phosphate-mannose-protein mannosyltransferase activity
protein O-linked mannosylation
protein mannosylation
GPI anchor biosynthetic process
GPI anchor metabolic process
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
mannosylation
glycolipid biosynthetic process
protein N-linked glycosylation
protein lipidation
lipoprotein biosynthetic process
phosphatidylinositol biosynthetic process
glycolipid metabolic process
liposaccharide metabolic process
protein O-linked glycosylation
lipoprotein metabolic process
membrane lipid biosynthetic process
isoprenoid metabolic process
phosphatidylinositol metabolic process
membrane lipid metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
protein glycosylation
macromolecule glycosylation
glycosylation
glycerophospholipid metabolic process
alcohol metabolic process
glycoprotein biosynthetic process
phospholipid metabolic process
glycerolipid metabolic process
glycoprotein metabolic process
organic hydroxy compound metabolic process
organophosphate biosynthetic process
lipid biosynthetic process