IPMK

Entrez Summary: N/A
UniProt Summary: Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). {ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Quercetin 20μM R08 exp517	-2.19
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.05
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2
UM131593 0.2μM R03 exp106	-1.96
Thapsigargin 0.005μM R07 exp407	-1.94
Colchicine 0.009μM R05 exp215	-1.93
Docetaxel 0.002μM R01 exp45	-1.9
UM0125461 0.74μM R02 exp84	-1.9
Taxol 0.004μM R03 exp103	-1.81
Cabazitaxel 0.001μM R05 exp223	-1.79
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.76
HMS-I1 1μM R01 exp46	-1.75
UMK57 1μM R01 exp59	-1.71
Cannabidiol 20μM R08 exp466	1.7
Disulfiram 4.3μM R06 exp281	1.81
EPZ-5676 30μM R05 exp233	1.83
RK-33 8μM R08 exp518	1.87
Rapamycin 10μM R00 exp30	1.94
UM0129480 7μM R02 exp85	1.94
Betulinic acid 10 to 15μM on day4 R05 exp222	1.98
BVD-523 15μM R02 exp67	2.01
Hypoxia 5%O2 R04 exp191	2.04
Oligomycin-A 2μM R00 exp25	2.04
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.05
Vemurafenib 6.6μM R08 exp434	2.13
PF-06409577 20μM R07 exp389	2.17
Phenformin 20μM R05 exp212	2.19
Amiloride 100μM R08 exp447	2.23
Nicotine 3000μM R08 exp510	2.38
BI-2536 0.0042μM R03 exp95	2.4
QNZ 0.01μM R05 exp241	2.47
Mubritinib 0.2μM R01 exp48	2.7
Rotenone 0.07μM R08 exp431	2.72
Chloramphenicol 20μM R00 exp13	2.8
Trimetrexate 0.03μM R08 exp535	2.85
Mubritinib 0.2μM R02 exp65	3.41
QNZ 0.01μM R08 exp439	3.84
Arsenate 40μM R06 exp264	4.89

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity
inositol-1,4,5-trisphosphate 6-kinase activity
inositol tetrakisphosphate 5-kinase activity
inositol tetrakisphosphate 3-kinase activity
inositol tetrakisphosphate 6-kinase activity
flavonoid binding
inositol-1,4,5-trisphosphate 3-kinase activity
inositol trisphosphate metabolic process
necroptotic process
inositol phosphate biosynthetic process
programmed necrotic cell death
necrotic cell death
inositol phosphate metabolic process
polyol biosynthetic process
polyol metabolic process
alcohol biosynthetic process
phosphatidylinositol metabolic process
organic hydroxy compound biosynthetic process
glycerophospholipid metabolic process
alcohol metabolic process
phospholipid metabolic process
glycerolipid metabolic process
organic hydroxy compound metabolic process
organophosphate biosynthetic process
small molecule biosynthetic process
nucleolus
organophosphate metabolic process
cellular lipid metabolic process
programmed cell death
cell death
lipid metabolic process
phosphorylation
ATP binding
small molecule metabolic process