PRICKLE1

Gene Information

Official Symbol: PRICKLE1
Official Name: prickle planar cell polarity protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 144165
UniProt: Q96MT3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009].
UniProt Summary: Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. {ECO:0000269|PubMed:21901791}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UMK57 0.6μM R03 exp107	-2.33
3-Bromopyruvate 7μM R04 exp175	-1.84
Wortmannin 5μM R00 exp38	1.7
Cabazitaxel 0.001μM R05 exp223	1.71
Cycloheximide 0.2μM R00 exp15	1.72
A-395 10μM R05 exp218	1.73
UNC2400 2μM R03 exp156	1.73
Oligomycin-A 20μM R00 exp26	1.74
Rotenone 2μM R00 exp33	1.84
Rifampicin 10μM R00 exp32	1.98
OICR-9429 10μM R03 exp142	2.1
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.48

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16463
Expression level (log2 read counts): 1.92

Expression Distribution

LIM
PET

regulation of cardiac muscle cell myoblast differentiation
negative regulation of cardiac muscle cell myoblast differentiation
negative regulation of cardioblast differentiation
regulation of cardioblast differentiation
negative regulation of stem cell differentiation
negative regulation of cardiocyte differentiation
negative regulation of myoblast differentiation
coronary vasculature development
regulation of cardiocyte differentiation
aorta development
regulation of myoblast differentiation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
artery development
neural tube closure
tube closure
protein import into nucleus
Wnt signaling pathway, planar cell polarity pathway
primary neural tube formation
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
neural tube formation
regulation of establishment of planar polarity
import into nucleus
positive regulation of protein ubiquitination
regulation of stem cell differentiation
positive regulation of proteolysis involved in cellular protein catabolic process
embryonic epithelial tube formation
regulation of proteasomal ubiquitin-dependent protein catabolic process
epithelial tube formation
non-canonical Wnt signaling pathway
positive regulation of protein modification by small protein conjugation or removal
positive regulation of cellular protein catabolic process
protein import
morphogenesis of embryonic epithelium
tube formation
regulation of ubiquitin-dependent protein catabolic process
neural tube development
protein localization to nucleus
negative regulation of canonical Wnt signaling pathway
regulation of morphogenesis of an epithelium