RMI2

Entrez Summary: N/A
UniProt Summary: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. {ECO:0000269|PubMed:18923082, ECO:0000269|PubMed:18923083, ECO:0000269|PubMed:27977684}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

maintenance of rDNA
maintenance of DNA repeat elements
negative regulation of double-strand break repair via homologous recombination
negative regulation of double-strand break repair
negative regulation of DNA repair
negative regulation of DNA recombination
regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
regulation of sister chromatid segregation
regulation of chromosome segregation
regulation of DNA recombination
negative regulation of DNA metabolic process
regulation of DNA repair
regulation of signal transduction by p53 class mediator
DNA replication
regulation of response to DNA damage stimulus
regulation of chromosome organization
regulation of DNA metabolic process
nuclear speck
DNA repair
regulation of cellular response to stress
DNA metabolic process
regulation of cell cycle process
cellular response to DNA damage stimulus
chromosome organization
regulation of cell cycle
regulation of organelle organization
negative regulation of nucleobase-containing compound metabolic process
DNA binding
regulation of response to stress
negative regulation of response to stimulus
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
regulation of intracellular signal transduction