SRGAP2C

Gene Information

Official Symbol: SRGAP2C
Official Name: SLIT-ROBO Rho GTPase activating protein 2C
Aliases and Previous Symbols: N/A
Entrez ID: 653464
UniProt: P0DJJ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory. {ECO:0000269|PubMed:22559944}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Actinomycin-D 0.01μM R00 exp4	-2.46
Etoposide 0.3μM R05 exp199	-2.09
Vinblastine 0.015μM R05 exp208	-1.84
Arsenate 40μM R06 exp264	-1.78
SB743921 0.001μM R05 exp244	-1.71
Deguelin 0.05μM R02 exp69	1.72
S-trityl-L-cysteine 0.5μM R05 exp243	1.77
Rifampicin 10μM R00 exp32	1.89
Cadmium 60μM R08 exp462	1.98
CCCP 1μM R00 exp11	2.02
Wortmannin 0.5μM R00 exp37	2.11
NFN1 0.4μM R03 exp99	2.14
Isoniazid 100μM R08 exp494	2.51

Gene	Correlation
WDR87	0.45
DTL	0.449
UPF1	0.447
SCAF1	0.438
TCEB3CL	0.431
TCEB3C	0.429
NUP153	0.417
ORC6	0.415
RPS2	0.409
TWISTNB	0.409
NPIPB5	0.408
HIVEP3	0.408
RPS19BP1	0.406
TCEB3CL2	0.406
ANKLE1	0.405
OGDH	0.402
C1QTNF9B	0.4

Essentiality in NALM6

Essentiality Rank: 1649
Expression level (log2 read counts): 4.98

Expression Distribution

pseudopodium assembly
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
pseudopodium organization
negative regulation of filopodium assembly
modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
cell motility involved in cerebral cortex radial glia guided migration
negative regulation of dendritic spine development
positive regulation of neuron migration
cerebral cortex radial glia guided migration
telencephalon glial cell migration
negative regulation of plasma membrane bounded cell projection assembly
negative regulation of dendrite development
cerebral cortex radially oriented cell migration
glial cell migration
regulation of neuron migration
cerebral cortex cell migration
regulation of filopodium assembly
Rac GTPase binding
telencephalon cell migration
forebrain cell migration
regulation of dendritic spine development
cerebral cortex development
regulation of dendrite development
negative regulation of neuron projection development
pallium development
negative regulation of cell projection organization
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
gliogenesis
negative regulation of neuron differentiation
telencephalon development
negative regulation of cell migration
negative regulation of cell motility
negative regulation of neurogenesis
negative regulation of cellular component movement
negative regulation of nervous system development
negative regulation of locomotion
negative regulation of cell development
forebrain development
plasma membrane bounded cell projection assembly