WSB1

Entrez Summary: N/A
UniProt Summary: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:15965468, ECO:0000269|PubMed:18093972}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CB-839 10μM R05 exp224	-4.01
Ethanol 0.01 R05 exp234	-2.94
QNZ 0.01μM R05 exp241	-2.83
THZ531 0.11μM R07 exp409	-2.65
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.57
Azithromycin 100μM R08 exp452	-2.54
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.27
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-2.18
Mubritinib 0.2μM R02 exp65	-2.11
Rapamycin 1μM R00 exp29	-1.97
Golgicide-A 2μM R03 exp121	-1.94
Rapamycin 2μM R07 exp306	-1.93
Mubritinib 0.2μM R01 exp48	-1.89
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.88
Dimethyloxaloylglycine 100μM R05 exp229	-1.88
GSK-LSD1 10μM R03 exp123	-1.8
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.79
Chloramphenicol 20μM R00 exp13	-1.79
EPZ-5676 30μM R05 exp233	-1.79
Oligomycin-A 2μM R00 exp25	-1.75
B02 10μM R08 exp453	-1.74
Phenformin 20μM R05 exp212	-1.72
AICAR 240μM R03 exp116	1.72
BI-2536 0.02μM R03 exp96	1.74
JQ1 0.8μM R08 exp435	1.74
ONC212 0.15μM R08 exp513	1.78
GSK-J4 1.5μM R08 exp441	2.19
Bortezomib 0.05μM R00 exp7	2.49
Q15 2.7μM R02 exp79	2.59

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
RPS6KB1	0.432
PMM2	0.401

SOCS box
WD40

intracellular
protein polyubiquitination
post-translational protein modification
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
intracellular signal transduction