Dimethyloxaloylglycine 11μM R07 exp314
Mechanism of Action
Prolylhydroxylase inhibitor, induces HIF-1α accumulation
- Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor
- Class / Subclass 2: Signal Transduction / Other inhibitor
Technical Notes
Compound References
- PubChem Name: Dimethyloxalylglycine
- Synonyms: Dimethyloxallyl Glycine
- CAS #: 89464-63-1
- PubChem CID: 560326
- IUPAC: methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate
- INCHI Name: InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
- INCHI Key: BNJOZDZCRHCODO-UHFFFAOYSA-N
- Molecular Weight: 175.14
- Canonical SMILES: COC(=O)CNC(=O)C(=O)OC
- Isomeric SMILES: N/A
- Molecular Formula: C6H9NO5
Compound Supplier
- Supplier Name: Toronto Research Chemicals
- Catalog #: D476325
- Lot #: 5-RUS-16-1
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C6H9NO5 176.05535; found 176.05545
Dose Response Curve
- Platform ID: DMOG
- Min: -16.4864; Max: 89.0929
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 6.0680 |
| IC30 | 8.8278 |
| IC40 | 12.6233 |
| IC50 | 18.2304 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 11µM
- Days of incubation: 8
- Doublings: 7.0
- Numbers of reads: 21046274
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 1/0 | Scores |
Dimethyloxaloylglycine 11μM R07 exp314
