Losmapimod 1μM R07 exp376 [The Human Chemical-Genetic Interaction Map Project]

Inhibits p38‘±/‘_ MAP kinases

Class / Subclass 1: Signal Transduction / Kinase Inhibitor

Compound References

PubChem Name: Losmapimod
Synonyms: GSK-AHAB; GW856553X; SB856553
CAS #: 585543-15-3
PubChem CID: 11552706
IUPAC: 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
INCHI Name: InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28)
INCHI Key: KKYABQBFGDZVNQ-UHFFFAOYSA-N
Molecular Weight: 383.5
Canonical SMILES: CC1=C(C=C(C=C1F)C(=O)NC2CC2)C3=NC=C(C=C3)C(=O)NCC(C)(C)C
Isomeric SMILES: N/A
Molecular Formula: C22H26FN3O2

Compound Supplier

Supplier Name: Selleck Chemicals
Catalog #: S7215
Lot #: S721 501

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C22H26FN3O2 384.20818; found 384.20948

Dose Response Curve

Platform ID: Losmapimod
Min: -20.8875; Max: -2.4013

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 07
Dose: 1µM
Days of incubation: 8
Doublings: 7.1
Numbers of reads: 22591304

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
VPS25	-3.16	0.20
VEZT	-2.67	0.10
ACTC1	-2.53	0.10
CRYBA2	-2.53	0.10
ORC3	-2.29	0.68
ST6GALNAC6	-2.21	0.41
VPS53	-2.20	0.68
ZNF681	-2.18	0.68
RSRC2	-2.15	0.78
PGGT1B	-2.09	0.68
ADNP	-2.05	0.68
CLMN	-2.04	0.68
ASB3	-2.04	0.68
BRIP1	-2.02	0.68
UBE2I	-2.00	0.68
EXOC3L1	-1.95	0.68
UST	-1.94	0.68
APBB1IP	-1.94	0.68
CCDC27	-1.93	0.68
PNRC2	-1.91	0.68
EFHC2	-1.90	0.68
PDE2A	-1.90	0.68
RSRC1	-1.88	0.68
FOXD4L1	-1.87	0.68
LDHA	-1.86	0.68
CLEC4F	-1.84	0.68
HDAC8	-1.83	0.68
IZUMO3	-1.83	0.68
NSD1	-1.83	0.68
KIF13A	-1.82	0.68
DENND3	1.95	0.65
ERN1	1.95	0.69
RPS14	1.96	0.69
PSMD1	1.96	0.72
FAM71E1	1.97	0.69
ARID3B	1.98	0.69
LOC100505679	2.00	0.81
KPNB1	2.01	0.81
RPS3A	2.03	0.69
CDK8	2.05	0.65
COPB1	2.08	0.72
SKIV2L	2.09	0.69
SEC13	2.10	0.69
MGST1	2.12	0.61
IQCG	2.13	0.52
ABCB10	2.13	0.52
GATSL1	2.15	0.57
NUP155	2.18	0.65
CCND3	2.22	0.69
FSCN3	2.23	0.52
AAAS	2.24	0.52
SCFD2	2.27	0.39
BCL11A	2.28	0.39
ZNF331	2.28	0.39
RANGAP1	2.30	0.57
LEPREL4	2.32	0.39
FAM9B	2.32	0.57
ECD	2.37	0.72
RAD51	2.39	0.65
PCNA	2.47	0.72

Last modified: 2026/01/15 21:36
by 127.0.0.1