GSK-J5 1.5μM R08 exp484
Mechanism of Action
Inactive isomer of GSKJ4
- Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor
Technical Notes
Compound References
- PubChem Name: Ethyl 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate;hydrochloride
- Synonyms: N/A
- CAS #: 1797983-32-4
- PubChem CID: 126456082
- IUPAC: ethyl 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate;hydrochloride
- INCHI Name: InChI=1S/C24H27N5O2.ClH/c1-2-31-23(30)9-13-26-21-16-22(28-24(27-21)20-8-5-12-25-17-20)29-14-10-18-6-3-4-7-19(18)11-15-29;/h3-8,12,16-17H,2,9-11,13-15H2,1H3,(H,26,27,28);1H
- INCHI Key: QQHQMHJAOKADED-UHFFFAOYSA-N
- Molecular Weight: 454
- Canonical SMILES: CCOC(=O)CCNC1=CC(=NC(=N1)C2=CN=CC=C2)N3CCC4=CC=CC=C4CC3.Cl
- Isomeric SMILES: N/A
- Molecular Formula: GAVFNLTSAD HLYVNVSELS LVNFEESQTF FGLYKL
Compound Supplier
- Supplier Name: Structural Genomics Consortium
- Catalog #: N/A
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C24H27N5O2 440.2057; found 440.20665
Dose Response Curve
- Platform ID: GSKJ5
- Min: -21.2198; Max: 8.1455
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 08
- Dose: 1.5µM
- Days of incubation: 8
- Doublings: 7.0
- Numbers of reads: 17373854
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
GSK-J5 1.5μM R08 exp484
