AFF1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.73
Isonicotinamide 500μM R03 exp129	1.75
UMK57 1μM R01 exp59	1.87
Metformin 40μM R03 exp132	1.88
R-DABN 8μM R03 exp111	1.88
GSK343 3μM R03 exp124	1.93
BML-284 0.09μM R08 exp460	1.98
Taxol 0.002μM R01 exp54	2.02
GSK591 2.6μM R03 exp128	2.11
Demecolcine 0.03μM R05 exp228	2.14
BI-D1870 3.15μM R02 exp66	2.24
3-Bromopyruvate 7μM R04 exp175	2.49
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.77
UM131593 0.2μM R03 exp106	2.89

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ELL-EAF complex
transcription elongation factor complex
double-stranded DNA binding
DNA-binding transcription factor activity