ARID2

Entrez Summary: This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1. [provided by RefSeq, Dec 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Actinomycin-D 0.01μM R00 exp4	-1.74
Alpha-Amanitin 0.5μM R00 exp5	1.7
WNT3A 44ng/ml R08 exp537	1.71
Campthothecin 0.001μM R06 exp270	1.77
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.78
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.91
Tunicamycin 0.04μM R07 exp418	2.01
Arsenate 40μM R06 exp264	2.03
AICAR 240μM R05 exp211	2.09
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.1
Rapamycin 10μM R00 exp30	2.35
TRAIL 5ng/ml R00 exp35	2.36
TRAIL 50ng/ml R00 exp36	2.77

Global Fraction of Cell Lines Where Essential: 10/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	5/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

RFX DNA binding
ARID

coronary artery morphogenesis
cardiac muscle cell proliferation
striated muscle cell proliferation
coronary vasculature morphogenesis
muscle cell proliferation
nucleosome disassembly
chromatin disassembly
protein-DNA complex disassembly
cardiac muscle tissue growth
heart growth
coronary vasculature development
artery morphogenesis
artery development
organ growth
chromatin assembly or disassembly
nucleosome organization
cardiac muscle tissue development
protein-containing complex disassembly
protein-DNA complex subunit organization
heart morphogenesis
negative regulation of cell migration
negative regulation of cell motility
striated muscle tissue development
muscle tissue development
negative regulation of cellular component movement
negative regulation of locomotion
developmental growth
growth
cellular component disassembly
blood vessel morphogenesis
embryonic organ development
blood vessel development
vasculature development
cardiovascular system development
heart development
cell population proliferation
tube morphogenesis
negative regulation of cell population proliferation
chromatin organization
tube development