ATP2C1

Entrez Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cryptotanshinone 12μM R05 exp227	-2.76
Senexin-A 25μM R07 exp400	-1.92
Amiloride 100μM R08 exp447	-1.73
Aphidicolin 0.4μM R08 exp440	-1.71
Nifuroxazide 5μM R03 exp102	-1.71
Lead acetate 2000μM R08 exp497	-1.7
Alpha-Amanitin 0.5μM R00 exp5	1.75
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.85
Cycloheximide 0.2μM R00 exp15	1.87
Bafilomycin-A1 0.009μM R08 exp454	2.01
Hydroxyurea 100μM R07 exp329	2.18
Pimelic-diphenylamide-106 0.5μM R00 exp27	2.28
Rifampicin 10μM R00 exp32	3.16
CoCl2 18μM R07 exp346	4.5

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Golgi calcium ion homeostasis
Golgi calcium ion transport
manganese transmembrane transporter activity, phosphorylative mechanism
manganese ion transmembrane transport
calcium transmembrane transporter activity, phosphorylative mechanism
manganese ion transport
proton-exporting ATPase activity, phosphorylative mechanism
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
actin cytoskeleton reorganization
transition metal ion transport
proton transmembrane transport
trans-Golgi network
positive regulation of I-kappaB kinase/NF-kappaB signaling
calcium ion transmembrane transport
regulation of I-kappaB kinase/NF-kappaB signaling
calcium ion transport
cell-cell adhesion via plasma-membrane adhesion molecules
divalent metal ion transport
divalent inorganic cation transport
monovalent inorganic cation transport
epidermis development
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
actin cytoskeleton organization
cell-cell adhesion
cellular metal ion homeostasis
inorganic cation transmembrane transport
actin filament-based process
cation transmembrane transport
Golgi membrane
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis