ATP6V1D

Entrez Summary: N/A
UniProt Summary: Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. {ECO:0000250, ECO:0000269|PubMed:21844891}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Clomiphene 4.4μM R02 exp68	-3.05
Etoposide 0.3μM R05 exp199	-2.45
Nocodazole 0.2μM R00 exp24	-2.41
Cryptotanshinone 12μM R05 exp227	-2.3
Bortezomib 0.05μM R00 exp7	-2.23
Salubrinal 20μM R07 exp399	-2.23
Bafilomycin-A1 0.009μM R08 exp454	-2.15
DABN 20μM R00 exp17	-2.12
Pyronaridine 1μM R06 exp295	-2.08
WNT3A 44ng/ml R08 exp537	-2.08
Sulforaphane 9μM R08 exp526 no dilution day6	-2.02
Etoposide 1μM R00 exp19	-2.01
Vemurafenib 6.6μM R02 exp89	-1.95
Hydroxyurea 100μM R07 exp329	-1.93
Cerivastatin 0.15μM R05 exp226	-1.88
Dimethyloxaloylglycine 11μM R07 exp314	-1.87
Pyridostatin 4μM R05 exp240	-1.86
Tanespimycin 14μM R08 exp527	-1.84
All-trans-Retinoic-Acid 40μM R07 exp334	-1.83
Bisphenol A 100μM R06 exp269	-1.77
Dimethyloxaloylglycine 100μM R05 exp229	-1.77
PU-H71 1μM R08 exp515	-1.76
EPZ-5676 30μM R05 exp233	-1.72
Taxol 0.004μM R03 exp103	-1.72
Tozasertib 0.1μM R07 exp414	-1.72
PFI-3 10μM R03 exp144	2.09

Global Fraction of Cell Lines Where Essential: 108/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	3/28
bone	3/26
breast	4/33
central nervous system	3/56
cervix	1/4
colorectal	3/17
esophagus	1/13
fibroblast	0/1
gastric	4/16
kidney	7/21
liver	4/20
lung	8/75
lymphocyte	0/16
ovary	7/26
pancreas	5/24
peripheral nervous system	3/16
plasma cell	6/15
prostate	0/1
skin	5/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	2/22
urinary tract	4/29
uterus	0/5

Expression Distribution

proton-transporting V-type ATPase complex
proton-transporting ATPase activity, rotational mechanism
phagosome acidification
transferrin transport
phagosome maturation
intracellular pH reduction
protein localization to cilium
pH reduction
ATPase-coupled transmembrane transporter activity
iron ion transport
regulation of intracellular pH
insulin receptor signaling pathway
regulation of cellular pH
specific granule membrane
regulation of pH
cellular monovalent inorganic cation homeostasis
transition metal ion transport
monovalent inorganic cation homeostasis
proton transmembrane transport
cellular response to insulin stimulus
regulation of macroautophagy
cilium
response to insulin
cellular response to peptide hormone stimulus
lysosomal membrane
cellular response to peptide
regulation of autophagy
cilium assembly
cilium organization
response to peptide hormone
monovalent inorganic cation transport
plasma membrane bounded cell projection assembly
cell projection assembly
response to peptide
neutrophil degranulation
centrosome
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation