C9orf41

Entrez Summary: N/A
UniProt Summary: N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L- histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA- His). {ECO:0000269|PubMed:26001783}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK626616 14μM R08 exp485	-2.51
AICAR 240μM R03 exp116	-2.2
Aphidicolin 0.4μM R08 exp440	-1.85
Quercetin 20μM R08 exp517	-1.85
BML-284 0.09μM R08 exp460	-1.83
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.83
Latrunculin-B 10μM R07 exp374	-1.7
Quinacrine 2.5μM R03 exp146	1.73
Rapamycin 10μM R00 exp30	1.87
Cerivastatin 0.15μM R05 exp226	1.94
Etoposide 0.1μM R05 exp198	2.11
VER-155008 3.9μM R06 exp301	2.2
MLN-4924 0.2μM R00 exp21	2.26
Methotrexate 0.01μM R08 exp501	2.29
Fluvastatin 2.2μM R06 exp282	2.71
Aminopterin 0.005μM R07 exp335	3.64
Arsenate 40μM R06 exp264	3.9

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

carnosine N-methyltransferase activity
carnosine metabolic process
histidine catabolic process
imidazole-containing compound catabolic process
histidine metabolic process
S-adenosylmethionine-dependent methyltransferase activity
imidazole-containing compound metabolic process
aromatic amino acid family catabolic process
aromatic amino acid family metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
methylation
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
drug metabolic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process