CMC2

Entrez Summary: N/A
UniProt Summary: May be involved in cytochrome c oxidase biogenesis. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
iCRT14 30μM R08 exp492	-2.66
CVT-10216 0.1μM R06 exp278	-2.43
IL-3 9ng/ml R08 exp493	-2.34
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.2
THZ1 0.06μM R08 exp531	-2.18
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.16
LY2090314 0.003μM R08 exp499	-2.13
BI-6727 0.04μM R03 exp98	-2.07
LY2090314 0.003μM R08 exp500 no dilution day6	-2.01
Phenformin 20μM R05 exp212	-2
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.99
R-DABN 8μM R03 exp111	-1.89
MLN-4924 2μM R00 exp22	-1.8
SNS-032 25μM R07 exp401	-1.74
SNS-032 15μM R08 exp443	-1.7
Vemurafenib 6.6μM R02 exp89	1.71
PT-1 25μM R07 exp392	1.78
CFI-400945 25μM R08 exp469	1.83
TRAIL 50ng/ml R00 exp36	1.83
Zebularine 20μM R07 exp423	1.83
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.85
ETC-159 50μM R08 exp480	1.91
BI-2536 0.001μM R01 exp41	2
5-Azacytidine 2μM R07 exp330	2.05
2-Methoxyestradiol 0.2μM R01 exp40	2.08
LB-100 4.1μM R02 exp72	2.2
Oligomycin-A 2μM R00 exp25	2.38
2-Methoxyestradiol 0.55μM R07 exp310	2.46
PU-H71 1μM R08 exp515	2.78

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution