ETFDH

Entrez Summary: This gene encodes a component of the electron-transfer system in mitochondria and is essential for electron transfer from a number of mitochondrial flavin-containing dehydrogenases to the main respiratory chain. Mutations in this gene are associated with glutaric acidemia. Alternatively spliced transcript variants that encode distinct isoforms have been observed. [provided by RefSeq, Aug 2013].
UniProt Summary: Accepts electrons from ETF and reduces ubiquinone.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-3.54
Bortezomib 0.005μM R00 exp6	-2.43
Deferoxamine 11μM R07 exp350	-2.3
Rifampicin 30μM R08 exp430	-2.24
CoCl2 18μM R07 exp346	-2.06
Cannabidiol 20μM R08 exp466	-1.95
MK-1775 0.32μM R02 exp75	-1.83
FK-506 5μM R07 exp358	-1.78
GSK-J4 1-1.25μM to day4 R07 exp363	-1.7
Deguelin 0.05μM R02 exp69	1.74
Arsenate 40μM R06 exp264	1.74
Nifuroxazide 5μM R03 exp102	1.77
Menadione 5μM R06 exp292	1.81
THZ531 0.11μM R07 exp409	1.81
A-196 10μM R03 exp114	1.83
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.83
Arsenic trioxide 60μM R08 exp449	1.93
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.93
ABT-702 5μM R06 exp261	1.99
LY2090314 0.003μM R08 exp499	2.1
Ethanol 0.01 R05 exp234	2.16
LY2090314 0.003μM R08 exp500 no dilution day6	2.16
BVD-523 15μM R02 exp67	2.23
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.25
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.37
Trimetrexate 0.03μM R08 exp535	3.03

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Thi4
ETF QO

oxidoreductase activity, oxidizing metal ions with flavin as acceptor
electron-transferring-flavoprotein dehydrogenase activity
ubiquinone binding
fatty acid beta-oxidation using acyl-CoA dehydrogenase
quinone binding
integral component of mitochondrial inner membrane
4 iron, 4 sulfur cluster binding
fatty acid beta-oxidation
flavin adenine dinucleotide binding
electron transfer activity
fatty acid oxidation
lipid oxidation
fatty acid catabolic process
mitochondrial membrane
respiratory electron transport chain
monocarboxylic acid catabolic process
oxidoreductase activity
cellular respiration
electron transport chain
cellular lipid catabolic process
lipid modification
energy derivation by oxidation of organic compounds
carboxylic acid catabolic process
organic acid catabolic process
lipid catabolic process
fatty acid metabolic process
mitochondrial matrix
response to oxidative stress
generation of precursor metabolites and energy
small molecule catabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process