GABPA
Gene Information
- Official Symbol: GABPA
- Official Name: GA binding protein transcription factor subunit alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 2551
- UniProt: Q06546
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.
Pfam Domains GO Terms
Pfam Domains
| GABP-alpha |
| Ets |
| SAM PNT |
GO Terms
| negative regulation of megakaryocyte differentiation |
| activating transcription factor binding |
| blastocyst formation |
| regulation of megakaryocyte differentiation |
| negative regulation of myeloid cell differentiation |
| cellular response to dopamine |
| response to dopamine |
| blastocyst development |
| cellular response to monoamine stimulus |
| cellular response to catecholamine stimulus |
| response to catecholamine |
| response to monoamine |
| cellular response to ammonium ion |
| negative regulation of hemopoiesis |
| response to ammonium ion |
| transcription regulatory region DNA binding |
| regulation of myeloid cell differentiation |
| nuclear chromatin |
| transcription coactivator activity |
| in utero embryonic development |
| chromatin binding |
| cellular response to drug |
| mitochondrion organization |
| negative regulation of immune system process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of hemopoiesis |
| transcription by RNA polymerase II |
| protein heterodimerization activity |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| cellular response to organic cyclic compound |
| cellular response to organonitrogen compound |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| cellular response to nitrogen compound |
| DNA-binding transcription factor activity |
| negative regulation of cell differentiation |
| negative regulation of transcription by RNA polymerase II |
| anatomical structure formation involved in morphogenesis |
| response to organic cyclic compound |
| negative regulation of developmental process |
| embryo development |
| response to organonitrogen compound |
| response to drug |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 5-Fluorouracil 20μM R00 exp2 | 2.05 |
| Etoposide 1μM R00 exp19 | 2.25 |
| Diepoxybutane 3μM R07 exp354 | 2.48 |
| Actinomycin-D 0.001μM R00 exp3 | 2.78 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.659 |
| DIABLO | 0.539 |
| APAF1 | 0.536 |
| PLAA | 0.529 |
| MFN1 | 0.521 |
| FAF2 | 0.516 |
| CASP9 | 0.516 |
| CYCS | 0.515 |
| MEAF6 | 0.51 |
| HSPD1 | 0.51 |
| BAK1 | 0.509 |
| ENY2 | 0.503 |
| SERF2 | 0.502 |
| UBQLN1 | 0.499 |
| VDAC2 | 0.494 |
| MARCH5 | 0.485 |
| NXT1 | 0.471 |
| DOHH | 0.467 |
| STAU1 | 0.462 |
| HCCS | 0.457 |
| UBE2K | 0.455 |
| ATAD1 | 0.446 |
| GFPT1 | 0.435 |
| BAP1 | 0.434 |
| TRIAP1 | 0.431 |
| FBXO11 | 0.43 |
| ATP5J | 0.422 |
| RPTOR | 0.412 |
| RNMT | 0.407 |
| PELO | 0.402 |
| RAD23B | 0.402 |
| DHPS | 0.402 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 12/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 2/75 |
| lymphocyte | 1/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 2/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 2/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1447
- Expression level (log2 read counts): 5.86
Expression Distribution
GABPA Expression in NALM6 Cells: 5.86
