GLMN

Gene Information

Official Symbol: GLMN
Official Name: glomulin, FKBP associated protein
Aliases and Previous Symbols: N/A
Entrez ID: 11146
UniProt: Q92990
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].
UniProt Summary: Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production. {ECO:0000269|PubMed:11571281, ECO:0000269|PubMed:12604780}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MLN-4924 0.2μM R00 exp21	-2.43
Nifuroxazide 5μM R03 exp102	-2.19
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.88
Nicotine 3000μM R08 exp510	-1.81
Chloramphenicol 20μM R00 exp13	1.72
Docetaxel 0.002μM R01 exp45	1.74
Vinblastine 0.2μM R03 exp108	1.79
PU-H71 1μM R08 exp515	1.8
Doxorubicin 0.02μM R08 exp478	1.86
Mdivi-1 15μM R05 exp217	1.86
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.91
BML-284 0.09μM R08 exp460	2.08
UM131593 0.2μM R03 exp106	2.24
5-Fluorouracil 20μM R00 exp2	2.4
Genistein 15μM R07 exp360	2.53
Actinomycin-D 0.001μM R00 exp3	3.09

Gene	Correlation
UBE2G1	0.583
FKBP5	0.557
UBA3	0.501
NAE1	0.456
CBX3	0.453
TMEM161B	0.433
UBE2M	0.431
THOC6	0.421
OTUD5	0.419
UBR5	0.413
SLC25A26	0.405
UBE2L3	0.404
TRIAP1	0.401

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	4/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2753
Expression level (log2 read counts): 5.17

Expression Distribution

ubiquitin-protein transferase inhibitor activity
hepatocyte growth factor receptor binding
cullin-RING ubiquitin ligase complex
Cul4A-RING E3 ubiquitin ligase complex
positive regulation of interleukin-2 biosynthetic process
Cul2-RING ubiquitin ligase complex
regulation of interleukin-2 biosynthetic process
positive regulation of interleukin-2 production
Cul3-RING ubiquitin ligase complex
regulation of interleukin-2 production
negative regulation of T cell proliferation
positive regulation of cytokine biosynthetic process
vasculogenesis
negative regulation of protein ubiquitination
negative regulation of lymphocyte proliferation
negative regulation of mononuclear cell proliferation
negative regulation of leukocyte proliferation
negative regulation of protein modification by small protein conjugation or removal
neural tube closure
tube closure
primary neural tube formation
regulation of cytokine biosynthetic process
neural tube formation
negative regulation of T cell activation
negative regulation of leukocyte cell-cell adhesion
regulation of proteasomal ubiquitin-dependent protein catabolic process
embryonic epithelial tube formation
epithelial tube formation
positive regulation of cytokine secretion
negative regulation of lymphocyte activation
morphogenesis of embryonic epithelium
tube formation
regulation of ubiquitin-dependent protein catabolic process
regulation of T cell proliferation
neural tube development
negative regulation of leukocyte activation
negative regulation of cell-cell adhesion
regulation of proteasomal protein catabolic process
negative regulation of cell activation
regulation of protein ubiquitination