KDM3B

Entrez Summary: N/A
UniProt Summary: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-2.1
UM0011500 5μM R05 exp245	-1.73
Sulforaphane 9μM R08 exp526 no dilution day6	1.72
SNS-032 15μM R08 exp443	1.73
B02 10μM R08 exp453	1.78
DABN racemic mixture R03 exp93	1.8
PFI-2 4μM R05 exp239	1.8
BRD2 inhibitor II 20μM R07 exp341	1.81
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.83
Ethanol 0.01 R05 exp234	1.91
Sulforaphane 9μM R08 exp525	1.91
Atovaquone 15μM R08 exp451	1.96
LY2090314 0.003μM R08 exp499	1.96
AICAR 240μM R03 exp116	1.99
Tubacin 1.6μM R07 exp416	2.04
Citral 50μM R06 exp274	2.06
LY2090314 0.003μM R08 exp500 no dilution day6	2.06
Nicotine 3000μM R08 exp510	2.06
CCT251545 20μM R07 exp326	2.13
Lead acetate 2000μM R08 exp497	2.16
MS023 2μM R03 exp134	2.21
THZ1 0.06μM R08 exp531	2.33
Milciclib 2μM R08 exp502	2.34
UM0125461 0.74μM R02 exp84	2.43
Lead acetate 2000μM R08 exp498 no dilution day6	2.56
Hippuristanol 0.12μM R08 exp488	2.67
QNZ 0.01μM R08 exp439	2.76
A-366 10μM R03 exp115	2.93
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.95

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
MAPKAP1	0.419
URM1	0.402

response to cisplatin
histone demethylase activity (H3-K9 specific)
histone H3-K9 demethylation
antioxidant activity
dioxygenase activity
histone lysine demethylation
histone demethylation
protein demethylation
protein dealkylation
demethylation
chromatin DNA binding
transcription regulatory region sequence-specific DNA binding
cellular oxidant detoxification
response to antineoplastic agent
cellular detoxification
chromatin
detoxification
cellular response to toxic substance
histone modification
covalent chromatin modification
response to toxic substance
chromatin organization
oxidation-reduction process
response to drug
chromosome organization