LDB1
Gene Information
- Official Symbol: LDB1
- Official Name: LIM domain binding 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 8861
- UniProt: Q86U70
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity). {ECO:0000250|UniProtKB:P70662}.
Pfam Domains GO Terms
Pfam Domains
| LIM bind |
GO Terms
| histone H3-K4 acetylation |
| positive regulation of hemoglobin biosynthetic process |
| regulation of hemoglobin biosynthetic process |
| transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery |
| LIM domain binding |
| negative regulation of erythrocyte differentiation |
| cerebellar Purkinje cell differentiation |
| mesendoderm development |
| beta-catenin-TCF complex |
| cerebellar Purkinje cell layer formation |
| cerebellar Purkinje cell layer morphogenesis |
| cell differentiation in hindbrain |
| cerebellar cortex formation |
| enhancer sequence-specific DNA binding |
| cerebellar Purkinje cell layer development |
| epithelial structure maintenance |
| gastrulation with mouth forming second |
| cerebellar cortex morphogenesis |
| cerebellum morphogenesis |
| hindbrain morphogenesis |
| cell leading edge |
| regulation of erythrocyte differentiation |
| cerebellar cortex development |
| histone H3 acetylation |
| regulation of DNA-templated transcription, elongation |
| anterior/posterior axis specification |
| RNA polymerase II activating transcription factor binding |
| protein self-association |
| regulation of cell-substrate junction assembly |
| regulation of focal adhesion assembly |
| somatic stem cell population maintenance |
| regulation of adherens junction organization |
| hair follicle development |
| regulation of hematopoietic stem cell differentiation |
| endoderm development |
| skin epidermis development |
| hair cycle process |
| molting cycle process |
| negative regulation of myeloid cell differentiation |
| axis specification |
| regulation of hematopoietic progenitor cell differentiation |
| regulation of cell junction assembly |
| molting cycle |
| hair cycle |
| cerebellum development |
| metencephalon development |
| histone acetylation |
| regulation of cell-matrix adhesion |
| regulation of stem cell differentiation |
| internal peptidyl-lysine acetylation |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| mesoderm development |
| stem cell population maintenance |
| maintenance of cell number |
| negative regulation of hemopoiesis |
| protein acetylation |
| hindbrain development |
| gastrulation |
| central nervous system neuron differentiation |
| protein acylation |
| tissue homeostasis |
| transcription factor complex |
| regulation of cell-substrate adhesion |
| anterior/posterior pattern specification |
| regulation of myeloid cell differentiation |
| nuclear chromatin |
| transcription corepressor activity |
| peptidyl-lysine modification |
| multicellular organismal homeostasis |
| regionalization |
| anatomical structure homeostasis |
| enzyme binding |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| histone modification |
| covalent chromatin modification |
| skin development |
| chromatin binding |
| positive regulation of cell adhesion |
| epidermis development |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| pattern specification process |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| transcription by RNA polymerase II |
| embryonic morphogenesis |
| protein-containing complex |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| regulation of cell adhesion |
| chromatin organization |
| negative regulation of cell differentiation |
| brain development |
| head development |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| protein homodimerization activity |
| peptidyl-amino acid modification |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| embryo development |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| cell-cell signaling |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| regulation of phosphorylation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| regulation of immune system process |
| RNA metabolic process |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 17/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 8/28 |
| bone | 0/25 |
| breast | 3/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 3/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2181
- Expression level (log2 read counts): 6.27
Expression Distribution
LDB1 Expression in NALM6 Cells: 6.27
