LZTR1

Entrez Summary: This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008].
UniProt Summary: Probable transcriptional regulator that may play a crucial role in embryogenesis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.65
SGC2043 10μM R03 exp152	-1.9
SB202190 10μM R03 exp148	-1.84
OICR-9429 10μM R03 exp142	-1.72
I-BRD9 4μM R07 exp365	1.73
BML-284 0.09μM R08 exp460	1.76
CAY10603 0.55μM R08 exp467	1.84
Lead acetate 2000μM R08 exp497	1.84
VER-155008 3.9μM R06 exp301	1.84
CR131-b 0.005μM R08 exp474	2.16
Genistein 15μM R07 exp360	2.26
Wortmannin 5μM R00 exp38	2.48
Staurosporine 0.02μM R08 exp524	2.7
Tubacin 1.6μM R07 exp416	2.96
GSK626616 14μM R08 exp485	3
Lead acetate 2000μM R08 exp498 no dilution day6	4.28

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ras GTPase binding
Cul3-RING ubiquitin ligase complex
negative regulation of Ras protein signal transduction
negative regulation of small GTPase mediated signal transduction
endomembrane system
recycling endosome membrane
regulation of Ras protein signal transduction
regulation of small GTPase mediated signal transduction
negative regulation of intracellular signal transduction
DNA-binding transcription factor activity
protein ubiquitination
protein modification by small protein conjugation
Golgi apparatus
protein modification by small protein conjugation or removal
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
regulation of intracellular signal transduction