MAPRE1

Gene Information

Official Symbol: MAPRE1
Official Name: microtubule associated protein RP/EB family member 1
Aliases and Previous Symbols: N/A
Entrez ID: 22919
UniProt: Q15691
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plus-end tracking protein (+TIP) that binds to the plus- end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:12388762). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vincristine 0.0005μM R04 exp190	-3.87
BML-284 0.09μM R08 exp460	-3.83
S-trityl-L-cysteine 0.5μM R05 exp243	-3.76
Colchicine 0.009μM R05 exp215	-3.61
LY2090314 0.003μM R08 exp500 no dilution day6	-3.23
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.75
Demecolcine 0.03μM R05 exp228	-2.72
Mdivi-1 15μM R05 exp217	-2.51
HMS-I1 1μM R01 exp46	-2.46
BI-6727 0.0125μM R03 exp97	-2.43
Taxol 0.004μM R03 exp103	-2.35
LY2090314 0.003μM R08 exp499	-2.27
Epothilone-B 0.0015μM R05 exp231	-2.01
BI-2536 0.0042μM R03 exp95	-1.97
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.8
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.78
Thimerosal 0.85μM R08 exp529	-1.72
HMS-I1 10μM R06 exp256	2.54
UMK57 1μM R01 exp59	3.58

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4151
Expression level (log2 read counts): 7.48

Expression Distribution

Gene	Correlation
KIF15	0.536
TACC3	0.476
DLGAP5	0.461

CH
EB1

positive regulation of microtubule plus-end binding
regulation of microtubule plus-end binding
cortical microtubule cytoskeleton
protein localization to microtubule plus-end
mitotic spindle astral microtubule end
protein localization to microtubule end
positive regulation of microtubule binding
cell projection membrane
regulation of microtubule binding
protein localization to microtubule
negative regulation of microtubule polymerization
microtubule plus-end binding
microtubule plus-end
spindle midzone
positive regulation of microtubule polymerization
positive regulation of microtubule polymerization or depolymerization
protein localization to microtubule cytoskeleton
negative regulation of microtubule polymerization or depolymerization
protein localization to cytoskeleton
regulation of microtubule polymerization
cytoplasmic microtubule
negative regulation of protein polymerization
regulation of microtubule polymerization or depolymerization
positive regulation of protein binding
ciliary basal body-plasma membrane docking
spindle assembly
spindle
positive regulation of protein polymerization
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
negative regulation of cytoskeleton organization
spindle organization
microtubule organizing center
organelle localization by membrane tethering
positive regulation of binding
membrane docking
regulation of microtubule cytoskeleton organization
protein C-terminus binding