MON2

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	-3.53
Palbociclib 1μM R07 exp382	-2.51
Sulforaphane 9μM R08 exp526 no dilution day6	-2.29
Q15 1 to 2μM on day4 R04 exp164	-2.24
JQ1 0.8μM R08 exp435	-2.16
CFI-400945 25μM R08 exp469	-2.04
5-Fluorouracil 20μM R00 exp2	-1.95
FK-506 5μM R07 exp358	-1.87
Sulforaphane 9μM R08 exp525	-1.82
Thioridazine 5μM R08 exp530	-1.79
EPZ-5676 30μM R05 exp233	-1.76
FK-506 30μM R07 exp359	-1.75
Wiskostatin 3μM R07 exp422	-1.73
UM0125461 0.74μM R02 exp84	-1.7

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Sec7 N
DUF1981

Golgi to endosome transport
post-Golgi vesicle-mediated transport
cytosolic transport
Golgi vesicle transport
protein transport
intracellular transport
peptide transport
amide transport
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport