NCKAP1L
Gene Information
- Official Symbol: NCKAP1L
- Official Name: NCK associated protein 1 like
- Aliases and Previous Symbols: N/A
- Entrez ID: 3071
- UniProt: P55160
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F- actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE- independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648). {ECO:0000250|UniProtKB:Q8K1X4, ECO:0000269|PubMed:16417406, ECO:0000269|PubMed:17696648, ECO:0000303|PubMed:20969869}.
Pfam Domains GO Terms
Pfam Domains
| Nckap1 |
GO Terms
| positive regulation of gamma-delta T cell differentiation |
| positive regulation of CD8-positive, alpha-beta T cell differentiation |
| negative regulation of myosin-light-chain-phosphatase activity |
| regulation of gamma-delta T cell differentiation |
| positive regulation of gamma-delta T cell activation |
| positive regulation of CD8-positive, alpha-beta T cell activation |
| regulation of CD8-positive, alpha-beta T cell differentiation |
| actin polymerization-dependent cell motility |
| regulation of gamma-delta T cell activation |
| regulation of myosin-light-chain-phosphatase activity |
| SCAR complex |
| positive regulation of B cell differentiation |
| positive regulation of phagocytosis, engulfment |
| positive regulation of membrane invagination |
| negative regulation of interleukin-17 production |
| regulation of CD8-positive, alpha-beta T cell activation |
| regulation of phagocytosis, engulfment |
| regulation of membrane invagination |
| maintenance of cell polarity |
| positive regulation of cell adhesion mediated by integrin |
| positive regulation of neutrophil chemotaxis |
| B cell homeostasis |
| positive regulation of granulocyte chemotaxis |
| protein kinase activator activity |
| regulation of B cell differentiation |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| regulation of neutrophil chemotaxis |
| positive regulation of neutrophil migration |
| regulation of interleukin-17 production |
| positive regulation of erythrocyte differentiation |
| erythrocyte development |
| T cell homeostasis |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| regulation of neutrophil migration |
| positive regulation of B cell proliferation |
| cortical actin cytoskeleton organization |
| regulation of granulocyte chemotaxis |
| negative regulation of interleukin-6 production |
| regulation of cell adhesion mediated by integrin |
| regulation of erythrocyte differentiation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of alpha-beta T cell differentiation |
| cortical cytoskeleton organization |
| lymphocyte homeostasis |
| Rac GTPase binding |
| myeloid cell development |
| positive regulation of alpha-beta T cell activation |
| regulation of CD4-positive, alpha-beta T cell activation |
| negative regulation of phosphoprotein phosphatase activity |
| ficolin-1-rich granule membrane |
| regulation of B cell proliferation |
| regulation of alpha-beta T cell differentiation |
| negative regulation of protein dephosphorylation |
| vascular endothelial growth factor receptor signaling pathway |
| positive regulation of phagocytosis |
| leukocyte homeostasis |
| erythrocyte differentiation |
| neutrophil chemotaxis |
| positive regulation of T cell differentiation |
| positive regulation of leukocyte chemotaxis |
| granulocyte chemotaxis |
| erythrocyte homeostasis |
| positive regulation of actin filament polymerization |
| neutrophil migration |
| positive regulation of myeloid cell differentiation |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| positive regulation of T cell proliferation |
| regulation of phagocytosis |
| secretory granule membrane |
| granulocyte migration |
| positive regulation of endocytosis |
| negative regulation of phosphatase activity |
| myeloid cell homeostasis |
| negative regulation of dephosphorylation |
| regulation of leukocyte chemotaxis |
| regulation of phosphoprotein phosphatase activity |
| positive regulation of protein polymerization |
| B cell receptor signaling pathway |
| myeloid leukocyte migration |
| positive regulation of leukocyte migration |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| positive regulation of chemotaxis |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| positive regulation of leukocyte proliferation |
| regulation of T cell differentiation |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| regulation of protein dephosphorylation |
| regulation of interleukin-6 production |
| leukocyte chemotaxis |
| positive regulation of leukocyte differentiation |
| regulation of T cell proliferation |
| regulation of actin filament polymerization |
| positive regulation of B cell activation |
| regulation of lymphocyte differentiation |
| regulation of phosphatase activity |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of hemopoiesis |
| regulation of leukocyte migration |
| establishment or maintenance of cell polarity |
| positive regulation of supramolecular fiber organization |
| homeostasis of number of cells |
| positive regulation of T cell activation |
| regulation of endocytosis |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| cell chemotaxis |
| regulation of dephosphorylation |
| regulation of chemotaxis |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of cytoskeleton organization |
| myeloid cell differentiation |
| regulation of leukocyte proliferation |
| regulation of protein polymerization |
| regulation of myeloid cell differentiation |
| Fc receptor signaling pathway |
| positive regulation of protein complex assembly |
| positive regulation of cell-cell adhesion |
| regulation of actin filament organization |
| protein-containing complex binding |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| GTPase activator activity |
| antigen receptor-mediated signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| activation of protein kinase activity |
| phagocytosis |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| positive regulation of lymphocyte activation |
| regulation of cellular component size |
| leukocyte migration |
| regulation of actin filament-based process |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of GTPase activity |
| positive regulation of cell activation |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein complex assembly |
| regulation of hemopoiesis |
| negative regulation of hydrolase activity |
| cell projection assembly |
| neuron projection morphogenesis |
| immune response-regulating cell surface receptor signaling pathway |
| regulation of GTPase activity |
| plasma membrane bounded cell projection morphogenesis |
| neutrophil degranulation |
| cell projection morphogenesis |
| neutrophil activation involved in immune response |
| actin cytoskeleton organization |
| neutrophil mediated immunity |
| positive regulation of cell migration |
| neutrophil activation |
| granulocyte activation |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| leukocyte degranulation |
| cell part morphogenesis |
| regulation of anatomical structure size |
| regulation of lymphocyte activation |
| myeloid leukocyte mediated immunity |
| positive regulation of cellular component biogenesis |
| myeloid cell activation involved in immune response |
| positive regulation of cell motility |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| chemotaxis |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| taxis |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| immune response-activating signal transduction |
| actin filament-based process |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| negative regulation of protein modification process |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| positive regulation of organelle organization |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| activation of immune response |
| regulation of cell activation |
| immune system development |
| positive regulation of transferase activity |
| neuron projection development |
| regulation of cell adhesion |
| regulation of cytokine production |
| regulated exocytosis |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of protein kinase activity |
| neuron development |
| cellular component morphogenesis |
| regulation of cell migration |
| positive regulation of immune response |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| leukocyte activation |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| negative regulation of cell death |
| regulation of cellular component movement |
| secretion by cell |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| response to drug |
| negative regulation of cellular protein metabolic process |
| export from cell |
| positive regulation of phosphorylation |
| cell activation |
| cell motility |
| localization of cell |
| immune effector process |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| regulation of organelle organization |
| locomotion |
| positive regulation of developmental process |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| homeostatic process |
| cell development |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1693
- Expression level (log2 read counts): 7.7
Expression Distribution
NCKAP1L Expression in NALM6 Cells: 7.7
