NFIA

Gene Information

Official Symbol: NFIA
Official Name: nuclear factor I A
Aliases and Previous Symbols: N/A
Entrez ID: 4774
UniProt: Q12857
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
5-Azacytidine 2μM R07 exp330	-2.34
TRAIL 50ng/ml R00 exp36	-2.13
Vincristine 0.0005μM R04 exp190	-2.01
Caffeine 2600μM R08 exp463	-1.99
Bafilomycin-A1 0.009μM R08 exp454	-1.91
BI-D1870 2μM R04 exp162	-1.78
Radicicol 0.16μM R05 exp242	-1.71
BH1 1μM R04 exp169	-1.7
BVD-523 15μM R02 exp67	1.76
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.83
Aphidicolin 0.4μM R08 exp440	2.8

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9706
Expression level (log2 read counts): 5.27

Expression Distribution

CTF NFI
NfI DNAbd pre-N
MH1

synapse maturation
ureter development
viral genome replication
viral life cycle
DNA replication
developmental maturation
synapse organization
renal system development
urogenital system development
transcription factor binding
chromatin binding
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
cell junction
DNA-binding transcription factor activity
viral process
symbiotic process
interspecies interaction between organisms
tube development
negative regulation of transcription by RNA polymerase II
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cellular macromolecule biosynthetic process
negative regulation of gene expression
positive regulation of RNA metabolic process
macromolecule biosynthetic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process