NOSIP

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bafilomycin-A1 0.009μM R08 exp454	-2.76
Clomiphene 4.4μM R02 exp68	-2.6
Vemurafenib 6.6μM R02 exp89	-2.33
Aminopterin 0.005μM R07 exp335	-2.17
YM155 0.001μM R08 exp432	-2.03
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.98
Tubacin 1.6μM R07 exp416	-1.97
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.95
Ethanol 0.01 R05 exp234	-1.94
Dynasore 7μM R08 exp436	-1.91
Oligomycin-A 2μM R00 exp25	-1.88
THZ531 0.11μM R07 exp409	-1.83
Cincreasin 100μM R08 exp473	-1.81
LB-100 2μM R05 exp210	-1.76
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.74
ML-792 0.2μM R08 exp505	-1.72
VER-155008 3.9μM R06 exp301	1.74
2-Deoxy-D-glucose 800μM R05 exp214	1.79
RK-33 8μM R08 exp518	2.14
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.34
Taxol 0.004μM R03 exp103	2.39
Milciclib 2μM R08 exp502	2.6

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of nitric-oxide synthase activity
negative regulation of monooxygenase activity
negative regulation of oxidoreductase activity
regulation of nitric-oxide synthase activity
regulation of monooxygenase activity
regulation of oxidoreductase activity
ubiquitin protein ligase activity
Golgi membrane
protein ubiquitination
protein modification by small protein conjugation
negative regulation of catalytic activity
protein modification by small protein conjugation or removal
negative regulation of molecular function
RNA binding