NPIPA5

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-2.1
Torin1 0.08μM R02 exp82	-1.99
Etoposide 1μM R00 exp19	-1.93
Rucaparib 6.5μM R08 exp520	-1.86
Oligomycin-A 20μM R00 exp26	-1.8
DABN 20μM R00 exp17	-1.73
MS094 2μM R03 exp136	-1.7
Vinorelbine 0.001μM R05 exp249	1.73
WNT3A 44ng/ml R08 exp537	1.73
Dynasore 7μM R08 exp436	1.74
Alda-1 10μM R06 exp262	1.76
39°C R06 exp303	1.81
Cannabidiol 13μM R08 exp465	1.81
All-trans-Retinoic-Acid 8μM R07 exp333	1.83
Talazoparib 0.006μM R06 exp299	1.85
CB-839 10μM R05 exp224	1.9
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.92
FBS-Wisent 0.1 R07 exp426	1.93
Campthothecin 0.001μM R06 exp270	1.96
UM0011500 5μM R05 exp245	1.99
Parthenolide 2.5μM R05 exp238	2.07
Bisphenol A 100μM R06 exp269	2.13
Epigallocatechin gallate 20μM R05 exp230	2.48
VE-822 0.04μM R06 exp300	2.5
HMS-I2 1μM R06 exp286	3.37

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
CACTIN	0.412
RRM1	0.412