PHIP

Gene Information

Official Symbol: PHIP
Official Name: pleckstrin homology domain interacting protein
Aliases and Previous Symbols: N/A
Entrez ID: 55023
UniProt: Q8WWQ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients. [provided by RefSeq, Oct 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotine 3000μM R08 exp510	-2.39
EPZ-5676 30μM R05 exp233	-2.27
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-2.2
Cannabidiol 20μM R08 exp466	-2.09
JQ1 0.01μM R03 exp130	-2.09
BVD-523 15μM R02 exp67	-1.89
Phenformin 20μM R03 exp143	-1.87
Nifuroxazide 5μM R03 exp102	-1.83
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.83
Azithromycin 100μM R08 exp452	-1.81
Taxol 0.004μM R03 exp103	-1.79
QNZ 0.01μM R05 exp241	-1.78
SGC0946 7μM R03 exp151	-1.74
UMK57 1μM R01 exp59	-1.73
CR131-b 0.005μM R08 exp474	1.75
Staurosporine 0.02μM R08 exp524	1.82
Selumetinib 20μM R02 exp81	1.84
Lead acetate 2000μM R08 exp497	1.87
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.97
Bortezomib 0.005μM R00 exp6	1.99
Wortmannin 0.5μM R00 exp37	2.01
Rapamycin 1μM R00 exp29	2.11
ML-792 0.2μM R08 exp505	2.16
Salinomycin 3.5μM R08 exp521	2.19
CFI-400945 25μM R08 exp469	2.23
TRAIL 5ng/ml R00 exp35	2.29
Q15 2.7μM R02 exp79	2.34
Bleomycin 5μM R08 exp459	2.48
Lead acetate 2000μM R08 exp498 no dilution day6	2.68
SNS-032 15μM R08 exp443	3.05
Hypoxia 5%O2 R04 exp191	3.55

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10706
Expression level (log2 read counts): 7.99

Expression Distribution

WD40
Bromodomain

positive regulation of insulin-like growth factor receptor signaling pathway
lysine-acetylated histone binding
insulin receptor binding
regulation of insulin-like growth factor receptor signaling pathway
positive regulation of mitotic nuclear division
positive regulation of nuclear division
insulin receptor signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
positive regulation of mitotic cell cycle
regulation of cell shape
regulation of extrinsic apoptotic signaling pathway
cellular response to insulin stimulus
regulation of mitotic nuclear division
regulation of nuclear division
negative regulation of apoptotic signaling pathway
response to insulin
cellular response to peptide hormone stimulus
positive regulation of cell cycle process
cellular response to peptide
positive regulation of cell cycle
response to peptide hormone
regulation of apoptotic signaling pathway
response to peptide
regulation of cell morphogenesis
transmembrane receptor protein tyrosine kinase signaling pathway
cellular response to organonitrogen compound
cellular response to hormone stimulus
positive regulation of organelle organization
regulation of mitotic cell cycle
cellular response to nitrogen compound
enzyme linked receptor protein signaling pathway
regulation of cell cycle process
negative regulation of apoptotic process
negative regulation of programmed cell death
response to hormone
positive regulation of cell population proliferation
negative regulation of cell death
response to organonitrogen compound
cellular response to oxygen-containing compound
regulation of anatomical structure morphogenesis