PSTK

Entrez Summary: N/A
UniProt Summary: Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Palbociclib 1μM R07 exp382	-3.01
Rotenone 2μM R00 exp33	-2.92
UM131593 0.2μM R03 exp106	-2.36
MK2206 4μM R08 exp504	-2.34
HMS-I1 10μM R06 exp256	-2.22
Brefeldin A 0.02μM R00 exp8	-2.19
MLN-4924 0.2μM R00 exp21	-2.11
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.02
5-Fluorouracil 20μM R00 exp2	-1.99
BML-284 0.09μM R08 exp460	-1.97
LY2090314 0.003μM R08 exp499	-1.97
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.94
ML-792 0.2μM R08 exp505	-1.91
UM0131023 0.05μM R05 exp248	-1.87
UM0125461 0.74μM R02 exp84	-1.86
Rapamycin 2μM R07 exp306	-1.83
Geldanamycin 0.01μM R05 exp235	-1.81
Thimerosal 0.85μM R08 exp529	-1.81
Dimethyloxaloylglycine 100μM R05 exp229	-1.78
Genistein 15μM R07 exp360	-1.78
INK128 0.2μM R02 exp70	-1.77
Cerivastatin 0.15μM R05 exp226	-1.76
Wortmannin 5μM R00 exp38	-1.76
S-trityl-L-cysteine 0.5μM R05 exp243	-1.75
LY2090314 0.003μM R08 exp500 no dilution day6	-1.73
Phenformin 20μM R03 exp143	-1.72
AICAR 240μM R03 exp116	-1.71
Celastrol 0.12μM R05 exp225	-1.71

Global Fraction of Cell Lines Where Essential: 156/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	8/28
bone	9/26
breast	7/33
central nervous system	20/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	1/1
gastric	0/16
kidney	5/21
liver	7/20
lung	15/75
lymphocyte	7/16
ovary	5/26
pancreas	3/24
peripheral nervous system	6/16
plasma cell	4/15
prostate	0/1
skin	9/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	0/22
urinary tract	3/29
uterus	1/5

Expression Distribution

selenocysteinyl-tRNA(Sec) biosynthetic process
tRNA binding
kinase activity
tRNA metabolic process
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
RNA biosynthetic process
cellular amide metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
phosphorylation
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression