REST
Gene Information
- Official Symbol: REST
- Official Name: RE1 silencing transcription factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 5978
- UniProt: Q13127
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010].
- UniProt Summary: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. {ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| regulation of amniotic stem cell differentiation |
| negative regulation of amniotic stem cell differentiation |
| negative regulation of dense core granule biogenesis |
| negative regulation of mesenchymal stem cell differentiation |
| regulation of dense core granule biogenesis |
| negative regulation of aldosterone metabolic process |
| negative regulation of cortisol biosynthetic process |
| negative regulation of aldosterone biosynthetic process |
| negative regulation of glucocorticoid biosynthetic process |
| negative regulation of glucocorticoid metabolic process |
| positive regulation of oxidative stress-induced neuron death |
| negative regulation of steroid hormone biosynthetic process |
| regulation of mesenchymal stem cell differentiation |
| regulation of cortisol biosynthetic process |
| regulation of aldosterone metabolic process |
| regulation of aldosterone biosynthetic process |
| regulation of glucocorticoid biosynthetic process |
| negative regulation of calcium ion-dependent exocytosis |
| positive regulation of stem cell population maintenance |
| regulation of glucocorticoid metabolic process |
| negative regulation of hormone biosynthetic process |
| regulation of steroid hormone biosynthetic process |
| cardiac muscle cell myoblast differentiation |
| histone H4 deacetylation |
| negative regulation of hormone metabolic process |
| cellular response to electrical stimulus |
| negative regulation of alcohol biosynthetic process |
| cardioblast differentiation |
| negative regulation by host of viral transcription |
| modification of synaptic structure |
| positive regulation of oxidative stress-induced cell death |
| regulation of ketone biosynthetic process |
| positive regulation of cellular response to oxidative stress |
| positive regulation of response to oxidative stress |
| negative regulation of oxidative stress-induced neuron death |
| negative regulation of stem cell differentiation |
| neuronal stem cell population maintenance |
| negative regulation of steroid biosynthetic process |
| negative regulation of regulated secretory pathway |
| negative regulation of steroid metabolic process |
| regulation of oxidative stress-induced neuron death |
| negative regulation of viral transcription |
| regulation of hormone biosynthetic process |
| regulation of stem cell population maintenance |
| negative regulation of exocytosis |
| RNA polymerase II core promoter sequence-specific DNA binding |
| myoblast differentiation |
| negative regulation of insulin secretion |
| regulation of hormone metabolic process |
| histone methyltransferase complex |
| response to electrical stimulus |
| regulation of calcium ion-dependent exocytosis |
| negative regulation of oxidative stress-induced cell death |
| negative regulation of cellular response to oxidative stress |
| negative regulation of peptide hormone secretion |
| negative regulation of response to oxidative stress |
| negative regulation of lipid biosynthetic process |
| histone deacetylation |
| response to ischemia |
| protein deacetylation |
| cellular response to glucocorticoid stimulus |
| transcriptional repressor complex |
| cellular response to corticosteroid stimulus |
| protein deacylation |
| macromolecule deacylation |
| negative regulation of hormone secretion |
| regulation of oxidative stress-induced cell death |
| regulation of viral transcription |
| somatic stem cell population maintenance |
| regulation of alternative mRNA splicing, via spliceosome |
| modification by host of symbiont morphology or physiology |
| regulation of cellular response to oxidative stress |
| regulation of alcohol biosynthetic process |
| interaction with symbiont |
| negative regulation of lipid metabolic process |
| regulation of response to oxidative stress |
| hematopoietic progenitor cell differentiation |
| regulation of steroid biosynthetic process |
| negative regulation of small molecule metabolic process |
| positive regulation of neuron death |
| negative regulation of viral process |
| regulation of mRNA splicing, via spliceosome |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| regulation of osteoblast differentiation |
| regulation of steroid metabolic process |
| cardiocyte differentiation |
| regulation of stem cell differentiation |
| negative regulation of protein secretion |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| stem cell population maintenance |
| regulation of RNA splicing |
| maintenance of cell number |
| regulation of mRNA processing |
| negative regulation of peptide secretion |
| response to glucocorticoid |
| positive regulation of cysteine-type endopeptidase activity |
| modification of morphology or physiology of other organism |
| stem cell differentiation |
| response to corticosteroid |
| regulation of regulated secretory pathway |
| regulation of cellular ketone metabolic process |
| positive regulation of endopeptidase activity |
| regulation of insulin secretion |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| regulation of lipid biosynthetic process |
| cellular response to steroid hormone stimulus |
| regulation of ossification |
| positive regulation of peptidase activity |
| negative regulation of secretion by cell |
| regulation of viral process |
| negative regulation of neuron death |
| regulation of peptide hormone secretion |
| negative regulation of multi-organism process |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| transcription regulatory region DNA binding |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of exocytosis |
| negative regulation of neuron differentiation |
| negative regulation of secretion |
| regulation of cysteine-type endopeptidase activity |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| regulation of hormone secretion |
| synapse organization |
| negative regulation of neurogenesis |
| regulation of neuron death |
| negative regulation of nervous system development |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| response to steroid hormone |
| regulation of mRNA metabolic process |
| transcription factor binding |
| negative regulation of cell development |
| response to hypoxia |
| positive regulation of proteolysis |
| response to decreased oxygen levels |
| histone modification |
| positive regulation of neuron differentiation |
| covalent chromatin modification |
| response to oxygen levels |
| chromatin binding |
| regulation of lipid metabolic process |
| cellular response to drug |
| regulation of endopeptidase activity |
| regulation of small molecule metabolic process |
| regulation of peptidase activity |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of protein secretion |
| positive regulation of neurogenesis |
| muscle structure development |
| negative regulation of transport |
| regulation of peptide secretion |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| cellular response to lipid |
| heart development |
| regulation of hormone levels |
| positive regulation of nervous system development |
| cellular response to organic cyclic compound |
| positive regulation of cell development |
| regulation of vesicle-mediated transport |
| hemopoiesis |
| cellular response to hormone stimulus |
| hematopoietic or lymphoid organ development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| regulation of neuron differentiation |
| negative regulation of cell population proliferation |
| DNA-binding transcription factor activity |
| positive regulation of cell death |
| chromatin organization |
| regulation of protein transport |
| negative regulation of cell differentiation |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| symbiotic process |
| regulation of secretion |
| regulation of neurogenesis |
| interspecies interaction between organisms |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| response to hormone |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| negative regulation of cell death |
| response to drug |
| regulation of protein localization |
| chromosome organization |
| response to abiotic stimulus |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of hydrolase activity |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11012
- Expression level (log2 read counts): 6.59
Expression Distribution
REST Expression in NALM6 Cells: 6.59
