RNF126

Gene Information

Official Symbol: RNF126
Official Name: ring finger protein 126
Aliases and Previous Symbols: N/A
Entrez ID: 55658
UniProt: Q9BV68
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008].
UniProt Summary: E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174). Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564). {ECO:0000250|UniProtKB:Q91YL2, ECO:0000269|PubMed:23277564, ECO:0000269|PubMed:23418353, ECO:0000269|PubMed:24275455, ECO:0000269|PubMed:24981174, ECO:0000305|PubMed:23026136}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ethanol 0.01 R05 exp234	-1.81
Dynasore 10μM R04 exp180	-1.75
Benzoate 20000μM R08 exp456	1.71
PU-H71 1μM R08 exp515	1.79
42°C R08 exp539	1.91
CAY10603 0.55μM R08 exp467	1.91
HMS-I1 1μM R01 exp46	1.95
UMK57 1μM R01 exp59	1.98

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2766
Expression level (log2 read counts): 5.67

Expression Distribution

Gene	Correlation
KCMF1	0.502
RCE1	0.426
OTUD5	0.419
AARS	0.41

zf-C3HC4
zf-rbx1

cytoplasm protein quality control by the ubiquitin-proteasome system
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
cellular response to misfolded protein
response to misfolded protein
protein quality control for misfolded or incompletely synthesized proteins
epidermal growth factor receptor binding
protein K63-linked ubiquitination
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of ERBB signaling pathway
protein K48-linked ubiquitination
protein monoubiquitination
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
retrograde transport, endosome to Golgi
cytosolic transport
cellular response to topologically incorrect protein
response to topologically incorrect protein
ubiquitin protein ligase activity
endosomal transport
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
negative regulation of signal transduction
proteolysis
negative regulation of cell communication
negative regulation of signaling
intracellular transport
regulation of cell population proliferation