SLC7A11
Gene Information
- Official Symbol: SLC7A11
- Official Name: solute carrier family 7 member 11
- Aliases and Previous Symbols: N/A
- Entrez ID: 23657
- UniProt: Q9UPY5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. {ECO:0000269|PubMed:15151999}.
Pfam Domains GO Terms
Pfam Domains
| AA permease |
GO Terms
| regulation of cysteine metabolic process |
| oligopeptide import across plasma membrane |
| dipeptide import across plasma membrane |
| cystine:glutamate antiporter activity |
| tripeptide transmembrane transport |
| regulation of glutathione biosynthetic process |
| glutathione transmembrane transport |
| dipeptide transmembrane transport |
| dipeptide transport |
| regulation of sulfur amino acid metabolic process |
| tripeptide transport |
| glutathione transport |
| regulation of glutamate metabolic process |
| glutamate homeostasis |
| regulation of glutamate receptor clustering |
| amino acid homeostasis |
| regulation of AMPA glutamate receptor clustering |
| regulation of glutamine family amino acid metabolic process |
| regulation of neutrophil apoptotic process |
| astrocyte projection |
| L-glutamate import across plasma membrane |
| oligopeptide transmembrane transport |
| oligopeptide transport |
| L-glutamate import |
| regulation of melanin biosynthetic process |
| regulation of secondary metabolite biosynthetic process |
| regulation of receptor clustering |
| regulation of secondary metabolic process |
| response to redox state |
| regulation of postsynaptic membrane organization |
| L-amino acid transmembrane transporter activity |
| regulation of sulfur metabolic process |
| amino acid import across plasma membrane |
| striatum development |
| L-glutamate transmembrane transport |
| negative regulation of oxidative stress-induced neuron death |
| amino acid import |
| subpallium development |
| modified amino acid transport |
| regulation of oxidative stress-induced neuron death |
| ventricular system development |
| lens fiber cell differentiation |
| regulation of myeloid cell apoptotic process |
| neurotransmitter uptake |
| regulation of cofactor metabolic process |
| lung alveolus development |
| platelet aggregation |
| sulfur compound transport |
| negative regulation of oxidative stress-induced cell death |
| negative regulation of cellular response to oxidative stress |
| cofactor transport |
| L-alpha-amino acid transmembrane transport |
| acidic amino acid transport |
| negative regulation of response to oxidative stress |
| visual learning |
| response to nicotine |
| brush border membrane |
| visual behavior |
| glutathione metabolic process |
| anion homeostasis |
| L-amino acid transport |
| homotypic cell-cell adhesion |
| rough endoplasmic reticulum |
| regulation of cellular amino acid metabolic process |
| regulation of oxidative stress-induced cell death |
| drug transmembrane transport |
| regulation of cellular response to oxidative stress |
| amino acid transmembrane transport |
| lens development in camera-type eye |
| associative learning |
| dicarboxylic acid transport |
| regulation of cellular amine metabolic process |
| regulation of leukocyte apoptotic process |
| regulation of response to oxidative stress |
| regulation of postsynapse organization |
| import across plasma membrane |
| amino acid transport |
| organic acid transmembrane transport |
| carboxylic acid transmembrane transport |
| platelet activation |
| adult behavior |
| learning |
| drug transport |
| lung development |
| regulation of cellular ketone metabolic process |
| respiratory tube development |
| neurotransmitter transport |
| appendage development |
| limb development |
| regulation of protein localization to membrane |
| respiratory system development |
| cellular modified amino acid metabolic process |
| negative regulation of neuron death |
| regulation of synapse organization |
| regulation of synapse structure or activity |
| cellular response to oxidative stress |
| telencephalon development |
| learning or memory |
| anion transmembrane transport |
| carboxylic acid transport |
| organic acid transport |
| blood coagulation |
| coagulation |
| hemostasis |
| cognition |
| response to light stimulus |
| regulation of neuron death |
| camera-type eye development |
| regulation of neurotransmitter levels |
| eye development |
| visual system development |
| cytoskeleton |
| sulfur compound metabolic process |
| sensory system development |
| leukocyte migration |
| response to oxidative stress |
| forebrain development |
| regulation of cellular amide metabolic process |
| regulation of small molecule metabolic process |
| cofactor metabolic process |
| response to radiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| organic anion transport |
| wound healing |
| regulation of body fluid levels |
| cell-cell adhesion |
| response to toxic substance |
| peptide metabolic process |
| regulation of cellular protein localization |
| sensory organ development |
| behavior |
| response to wounding |
| anion transport |
| cell surface |
| import into cell |
| epithelial cell differentiation |
| regulation of protein transport |
| regulation of cellular response to stress |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| head development |
| cellular amide metabolic process |
| ion homeostasis |
| tube development |
| regulation of cellular localization |
| response to organic cyclic compound |
| cell adhesion |
| biological adhesion |
| ion transmembrane transport |
| cell migration |
| central nervous system development |
| negative regulation of cell death |
| response to drug |
| regulation of protein localization |
| cell activation |
| localization of cell |
| cell motility |
| chemical homeostasis |
| epithelium development |
| response to abiotic stimulus |
| transmembrane transport |
| locomotion |
| ion transport |
| nervous system process |
| regulation of response to stress |
| peptide transport |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| amide transport |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| regulation of cell death |
| cellular response to stress |
| tissue development |
| nitrogen compound transport |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| GCLM | 0.428 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13008
- Expression level (log2 read counts): 4.58
Expression Distribution
SLC7A11 Expression in NALM6 Cells: 4.58
