SP3

Gene Information

Official Symbol: SP3
Official Name: Sp3 transcription factor
Aliases and Previous Symbols: N/A
Entrez ID: 6670
UniProt: Q02447
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010].
UniProt Summary: Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11μM R07 exp409	-2.16
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.89
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.82
MLN-4924 0.2μM R00 exp21	-1.75
B02 10μM R08 exp453	1.72
Staurosporine 0.02μM R08 exp524	1.72
Mitomycin-C 0.06μM R08 exp503	1.75
Tanespimycin 14μM R08 exp527	1.84
Menadione 5μM R06 exp292	1.88
Quercetin 20μM R08 exp517	1.89
Nutlin-3A 1.6μM R06 exp294	1.95
Trimetrexate 0.03μM R08 exp535	1.95
Vinblastine 0.002μM R01 exp60	1.98
Mdivi-1 15μM R05 exp217	2.02
TRAIL 5ng/ml R00 exp35	2.47
UMK57 1μM R01 exp59	2.87
BML-284 0.09μM R08 exp460	2.96
TRAIL 50ng/ml R00 exp36	3.19
UM131593 0.2μM R03 exp106	3.2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2691
Expression level (log2 read counts): 7.17

Expression Distribution

Gene	Correlation
FBXO11	0.543
TP53	0.506
KHDRBS1	0.45
ZNF592	0.44
UBE3A	0.425
MED23	0.42
ACTB	0.417
BAP1	0.402
ID3	0.4
FKBP5	0.4

embryonic process involved in female pregnancy
enucleate erythrocyte differentiation
natural killer cell differentiation
trophectodermal cell differentiation
definitive hemopoiesis
monocyte differentiation
mononuclear cell differentiation
granulocyte differentiation
megakaryocyte differentiation
embryonic camera-type eye morphogenesis
proximal promoter sequence-specific DNA binding
embryonic eye morphogenesis
embryonic camera-type eye development
blastocyst formation
protein-DNA complex
transcriptional repressor complex
natural killer cell activation
erythrocyte differentiation
embryonic placenta development
erythrocyte homeostasis
blastocyst development
PML body
myeloid cell homeostasis
B cell differentiation
myeloid leukocyte differentiation
camera-type eye morphogenesis
liver development
embryonic skeletal system development
hepaticobiliary system development
T cell differentiation
eye morphogenesis
placenta development
B cell activation
lung development
respiratory tube development
female pregnancy
respiratory system development
homeostasis of number of cells
multi-multicellular organism process
myeloid cell differentiation