SPTSSA

Entrez Summary: N/A
UniProt Summary: Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2- SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16- CoA as substrates, with a slight preference for C14-CoA. {ECO:0000269|PubMed:19416851}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 47/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	5/28
bone	1/26
breast	1/33
central nervous system	2/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	6/21
liver	2/20
lung	3/75
lymphocyte	1/16
ovary	3/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	3/29
uterus	1/5

Expression Distribution

serine C-palmitoyltransferase activity
serine C-palmitoyltransferase complex
ceramide biosynthetic process
ceramide metabolic process
sphingolipid biosynthetic process
membrane lipid biosynthetic process
sphingolipid metabolic process
membrane lipid metabolic process
amide biosynthetic process
lipid biosynthetic process
cellular amide metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum
lipid metabolic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process