STARD3

Entrez Summary: N/A
UniProt Summary: Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544). {ECO:0000269|PubMed:11053434, ECO:0000269|PubMed:12070139, ECO:0000269|PubMed:15930133, ECO:0000269|PubMed:19965586, ECO:0000269|PubMed:21322544, ECO:0000269|PubMed:22514632, ECO:0000269|PubMed:24105263, ECO:0000269|PubMed:28377464}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LJH685 50μM R08 exp433	-2.66
Trimetrexate 0.03μM R08 exp535	-2.21
Hypoxia 5%O2 R04 exp191	-2.11
5-Fluorouracil 20μM R00 exp2	-2.1
Resveratrol 16μM R03 exp147	-1.81
Quinacrine 2.5μM R03 exp146	-1.78
UM0125461 0.74μM R02 exp84	-1.77
IL-3 9ng/ml R08 exp493	-1.71
NMS-873 0.07μM R07 exp380	1.77
UM0011500 5μM R05 exp245	1.82
Isoniazid 100μM R08 exp494	1.83
Daidzin 10μM R06 exp280	1.89
Parthenolide 2.5μM R05 exp238	1.89
Fluvastatin 2.2μM R06 exp282	1.98
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	2.44
MK2206 4μM R08 exp504	2.51

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MENTAL
START

vesicle tethering to endoplasmic reticulum
progesterone biosynthetic process
endoplasmic reticulum-endosome membrane contact site
organelle membrane contact site
vesicle tethering
progesterone metabolic process
C21-steroid hormone biosynthetic process
ketone biosynthetic process
C21-steroid hormone metabolic process
steroid hormone biosynthetic process
cholesterol binding
cholesterol transport
hormone biosynthetic process
sterol transport
cellular ketone metabolic process
vesicle targeting
cholesterol metabolic process
late endosome membrane
cellular hormone metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
sterol metabolic process
organic hydroxy compound transport
establishment of vesicle localization
vesicle localization
hormone metabolic process
mitochondrial transport
steroid metabolic process
lipid transport
lysosomal membrane
alcohol metabolic process
lipid localization
establishment of organelle localization
organic hydroxy compound metabolic process
drug metabolic process
regulation of hormone levels
lipid biosynthetic process
organelle localization
small molecule biosynthetic process
protein homodimerization activity