STIP1

Entrez Summary: N/A
UniProt Summary: Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Temozolomide 200μM R04 exp189	-2.14
Lead acetate 2000μM R08 exp498 no dilution day6	-2.13
iCRT14 30μM R08 exp492	-2.06
Radicicol 0.16μM R05 exp242	-1.97
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.94
Bisphenol F 50μM R08 exp457	-1.78
Nutlin-3A 1.6μM R06 exp294	1.73
Actinomycin-D 0.001μM R00 exp3	1.74
Mitomycin-C 0.06μM R08 exp503	1.79
Doxorubicin 0.02μM R08 exp478	1.84
Metformin 40μM R03 exp132	1.89
Demecolcine 0.03μM R05 exp228	1.9
Dynasore 10μM R04 exp180	1.9
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.95
VER-155008 3.9μM R06 exp301	1.97
Resveratrol 16μM R03 exp147	1.98
Rotenone 20μM R00 exp34	2.03
Colchicine 0.009μM R05 exp215	2.07
Aphidicolin 0.4μM R08 exp440	2.11
Dexamethasone 0.006μM R07 exp351	2.17
TRAIL 5ng/ml R00 exp35	2.24
Methotrexate 0.01μM R08 exp501	2.25
Hydroxyurea 100μM R07 exp329	2.41
Nifuroxazide 1μM R01 exp51	2.5
AICAR 240μM R05 exp211	2.54
TRAIL 50ng/ml R00 exp36	2.79
Olaparib 4μM R08 exp512	2.81
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	4.54

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

chaperone complex
response to interleukin-7
cellular response to interleukin-7
Hsp90 protein binding
Hsp70 protein binding
chaperone binding
protein C-terminus binding
protein-containing complex
Golgi apparatus
cellular response to cytokine stimulus
response to cytokine
RNA binding