UBE2M

Entrez Summary: N/A
UniProt Summary: Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:15361859}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 673/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	25/28
blood	28/28
bone	25/26
breast	27/33
central nervous system	45/56
cervix	4/4
colorectal	15/17
esophagus	13/13
fibroblast	1/1
gastric	14/16
kidney	19/21
liver	19/20
lung	65/75
lymphocyte	16/16
ovary	23/26
pancreas	22/24
peripheral nervous system	14/16
plasma cell	15/15
prostate	1/1
skin	22/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	20/22
urinary tract	26/29
uterus	4/5

Expression Distribution

NEDD8 transferase activity
protein neddylation
positive regulation of neuron apoptotic process
positive regulation of neuron death
regulation of neuron apoptotic process
ubiquitin-protein transferase activity
regulation of neuron death
post-translational protein modification
positive regulation of apoptotic process
positive regulation of programmed cell death
protein ubiquitination
positive regulation of cell death
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
ATP binding
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death