UCHL5

Gene Information

Official Symbol: UCHL5
Official Name: ubiquitin C-terminal hydrolase L5
Aliases and Previous Symbols: N/A
Entrez ID: 51377
UniProt: Q9Y5K5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. {ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:18922472}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I2 10μM R06 exp288	-3.19
HMS-I2 5μM R06 exp287	-2.62
Rotenone 20μM R00 exp34	-2.05
Artemisinin 50μM R08 exp450	-1.92
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.83
MK-1775 0.32μM R02 exp75	-1.83
LLY-283 2.6μM R06 exp290	-1.8
3-Bromopyruvate 7μM R04 exp175	-1.78
LB-100 2μM R05 exp210	-1.71
BI-2536 0.0042μM R03 exp95	1.76
Nifuroxazide 5μM R03 exp102	1.78
5-Azacytidine 2μM R07 exp330	1.92
Cerivastatin 0.15μM R05 exp226	1.96
LY2090314 0.003μM R08 exp500 no dilution day6	1.99
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.02
Q15 2.7μM R02 exp79	2.08
RO-3307 4.7μM R02 exp80	2.1
Fluvastatin 2.2μM R06 exp282	2.22
I-BRD9 4μM R07 exp365	2.22
Dimethyloxaloylglycine 100μM R05 exp229	2.25
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.33
ML-792 0.2μM R08 exp505	2.42
LY2090314 0.003μM R08 exp499	2.62
THZ531 0.225μM R08 exp444	2.88
MLN-4924 0.2μM R00 exp21	3.11
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	3.18
Tubacin 1.6μM R07 exp416	4.32
UM0125461 0.74μM R02 exp84	4.87

Global Fraction of Cell Lines Where Essential: 8/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/25
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	1/21
liver	0/20
lung	2/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6664
Expression level (log2 read counts): 5.56

Expression Distribution

Gene	Correlation
NFRKB	0.784
TFPT	0.578
INO80E	0.568
ACTR5	0.553
INO80	0.543
PIH1D1	0.46
INO80C	0.435
INO80B	0.41

Ino80 complex
proteasome binding
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
endopeptidase inhibitor activity
negative regulation of ubiquitin-dependent protein catabolic process
proteasome complex
negative regulation of proteasomal protein catabolic process
negative regulation of proteolysis involved in cellular protein catabolic process
negative regulation of cellular protein catabolic process
thiol-dependent ubiquitin-specific protease activity
regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
DNA recombination
negative regulation of endopeptidase activity
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
negative regulation of peptidase activity
protein deubiquitination
protein modification by small protein removal
negative regulation of catabolic process
negative regulation of proteolysis
regulation of protein catabolic process
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
DNA repair
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
regulation of proteolysis
DNA metabolic process
cellular response to DNA damage stimulus
negative regulation of catalytic activity
regulation of cellular catabolic process