UFC1

Entrez Summary: N/A
UniProt Summary: E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. {ECO:0000269|PubMed:15071506}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-3.16
Golgicide-A 4μM R03 exp122	-2.7
Methotrexate 0.01μM R08 exp501	-2.41
Thapsigargin 0.005μM R07 exp407	-2.13
Cadmium 60μM R08 exp462	-2.11
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.88
Rapamycin 1μM R00 exp29	-1.83
Rapamycin 10μM R00 exp30	-1.79
UM0011500 10μM R05 exp246	-1.77
Rifampicin 1μM R00 exp31	-1.75
MS094 2μM R03 exp136	-1.71
NFN1 1μM R03 exp100	1.7
Vemurafenib 6.6μM R08 exp434	1.8
iCRT14 30μM R08 exp492	1.81
Arsenate 40μM R06 exp264	1.85
LLY-283 2.6μM R06 exp290	1.89
BI-6727 0.0125μM R03 exp97	1.91
BI-6727 0.04μM R03 exp98	1.95
HMS-I1 10μM R06 exp256	1.95
MS023 7μM R03 exp135	2
AICAR 240μM R03 exp116	2.03
QNZ 0.01μM R08 exp439	2.07
Trimetrexate 0.03μM R08 exp535	2.12
ML-792 0.2μM R08 exp505	2.16
Mubritinib 0.2μM R01 exp48	2.17
Etoposide 0.1μM R05 exp198	2.26
Taxol 0.004μM R03 exp103	2.63

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

UFM1 transferase activity
protein K69-linked ufmylation
protein polyufmylation
protein ufmylation
response to endoplasmic reticulum stress
brain development
protein modification by small protein conjugation
head development
central nervous system development
protein modification by small protein conjugation or removal
cellular response to stress