UFM1

Gene Information
  • Official Symbol: UFM1
  • Official Name: ubiquitin fold modifier 1
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 51569
  • UniProt: P61960
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable). {ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:25219498, ECO:0000305|PubMed:23152784}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 9623
  • Expression level (log2 read counts): 5.98

Expression Distribution

  • Last modified: 2026/01/07 22:37
  • by 127.0.0.1