ZC3H13

Entrez Summary: N/A
UniProt Summary: Acts as component of the WTAP complex that is involved in RNA processing and cell cycle (PubMed:24100041). {ECO:0000269|PubMed:24100041}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
FBS-Wisent 0.1 R07 exp426	-2.5
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-2.35
A-395N 10μM R05 exp219	-2.11
LJH685 50μM R08 exp433	-2.01
Tunicamycin 0.04μM R07 exp418	-2.01
Colchicine 0.009μM R05 exp215	-1.94
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.85
Cyclosporin-A 0.8μM R07 exp347	-1.82
Nifuroxazide 1μM R01 exp51	-1.82
Ribavirin 10μM R01 exp52	-1.81
Taxol 0.002μM R01 exp54	-1.78
BI-2536 0.001μM R01 exp41	-1.77
Wiskostatin 3μM R07 exp422	-1.71
Aminopterin 0.005μM R07 exp335	-1.7
Nicotinamide Riboside 100μM R03 exp139	1.81
Q15 2.7μM R02 exp79	1.94
IU1-C 25μM R04 exp183	2.06
PNU96415E 10μM R03 exp145	2.21
Citral 50μM R06 exp274	2.32
Metformin 40μM R03 exp132	2.32

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	1/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

RNA N6-methyladenosine methyltransferase complex
mRNA methylation
mRNA modification
regulation of stem cell population maintenance
RNA methylation
RNA modification
macromolecule methylation
methylation
RNA splicing
nuclear speck
mRNA processing
mRNA metabolic process
RNA processing
RNA binding
RNA metabolic process
gene expression