ZRANB2

Entrez Summary: N/A
UniProt Summary: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'- splice site selection. {ECO:0000269|PubMed:11448987}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-J4 1μM R07 exp362	-2.98
Curcumin 6.5μM R06 exp277	-2.54
GSK-J4 1-1.25μM to day4 R07 exp363	-2.44
VHL-ligand-1 20μM R07 exp421	-2.28
BN82002 4μM R07 exp340	-1.95
Cyclosporin-A 3μM R07 exp348	-1.94
Nifuroxazide 1μM R01 exp51	-1.93
Dimethyloxaloylglycine 100μM R05 exp229	-1.88
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.85
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.84
PFI-2 4μM R05 exp239	-1.84
NMS-873 0.07μM R07 exp380	-1.83
Tenofovir 10μM R07 exp405	-1.79
Trichostatin-A 0.06μM R07 exp415	-1.74
Ethanol 0.01 R05 exp234	-1.73
Lenalidomide 20μM R07 exp375	-1.72
Nutlin-3A 1.6μM R06 exp294	1.78
UM0129480 7μM R02 exp85	1.85
2-Methoxyestradiol 0.2μM R01 exp40	1.89
Tanespimycin 14μM R08 exp527	1.9
BI-2536 0.0042μM R03 exp95	1.97
Doxorubicin 0.02μM R08 exp478	2.15
BI-6727 0.0125μM R03 exp97	3.28

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	1/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lipopolysaccharide binding
RNA splicing
mRNA processing
DNA-binding transcription factor activity
mRNA metabolic process
RNA processing
RNA binding
RNA metabolic process
gene expression