PNU96415E 10μM R03 exp145
Mechanism of Action
Antagonist of DRD4 and 5-HT2A receptors
- Class / Subclass 1: Signal Transduction / GPCR Antagonist
Technical Notes
Protein References
- PubChem Name: 1-(4-Fluorophenyl)-4-(2-(isochroman-1-yl)ethyl)piperazine dihydrochloride
- Synonyms: N/A
- CAS #: 170856-41-4
- PubChem CID: 9909647
- IUPAC: 1-[2-(3,4-dihydro-1H-isochromen-1-yl)ethyl]-4-(4-fluorophenyl)piperazine;dihydrochloride
- INCHI Name: InChI=1S/C21H25FN2O.2ClH/c22-18-5-7-19(8-6-18)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-25-21;;/h1-8,21H,9-16H2;2*1H
- INCHI Key: OGMGYKPECFQXJJ-UHFFFAOYSA-N
- Molecular Weight: 413.4
- Canonical SMILES: C1COC(C2=CC=CC=C21)CCN3CCN(CC3)C4=CC=C(C=C4)F.Cl.Cl
- Isomeric SMILES: N/A
- Molecular Formula: C21H27Cl2FN2O
Protein Supplier
- Supplier Name: Tocris Bioscience
- Catalog #: 2735
- Lot #: 2A/162592
Protein Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H25FN2O 341.20237; found 341.20324
Dose Response Curve
- Platform ID: PNU96415E
- Min: -0.8703; Max: 23.0371
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 10µM
- Days of incubation: 8
- Doublings: 8.0
- Numbers of reads: 10007799
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 1/0 | Scores |
PNU96415E 10μM R03 exp145
