EIF4G1
Gene Information
- Official Symbol: EIF4G1
- Official Name: eukaryotic translation initiation factor 4 gamma 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1981
- UniProt: Q04637
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| MIF4G |
| W2 |
| MA3 |
GO Terms
| regulation of eukaryotic translation initiation factor 4F complex assembly |
| positive regulation of eukaryotic translation initiation factor 4F complex assembly |
| regulation of mRNA cap binding |
| positive regulation of mRNA cap binding |
| positive regulation of miRNA mediated inhibition of translation |
| regulation of polysome binding |
| regulation of miRNA mediated inhibition of translation |
| cap-dependent translational initiation |
| positive regulation of mRNA binding |
| positive regulation of RNA binding |
| regulation of mRNA binding |
| eukaryotic initiation factor 4E binding |
| regulation of RNA binding |
| eukaryotic translation initiation factor 4F complex |
| negative regulation of peptidyl-threonine phosphorylation |
| translation initiation factor binding |
| positive regulation of gene silencing by miRNA |
| translation factor activity, RNA binding |
| positive regulation of posttranscriptional gene silencing |
| regulation of presynapse assembly |
| cytoplasmic translational initiation |
| regulation of presynapse organization |
| behavioral fear response |
| behavioral defense response |
| fear response |
| energy homeostasis |
| positive regulation of G1/S transition of mitotic cell cycle |
| polysome |
| regulation of peptidyl-threonine phosphorylation |
| positive regulation of cell cycle G1/S phase transition |
| molecular adaptor activity |
| translation initiation factor activity |
| multicellular organismal response to stress |
| cytoplasmic translation |
| positive regulation of mitotic cell cycle phase transition |
| regulation of translational initiation |
| negative regulation of autophagy |
| regulation of gene silencing by miRNA |
| regulation of posttranscriptional gene silencing |
| regulation of gene silencing by RNA |
| positive regulation of cell cycle phase transition |
| regulation of synapse assembly |
| positive regulation of peptidyl-serine phosphorylation |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| regulation of gene silencing |
| regulation of peptidyl-serine phosphorylation |
| translational initiation |
| regulation of G1/S transition of mitotic cell cycle |
| positive regulation of mitotic cell cycle |
| mRNA binding |
| positive regulation of cell growth |
| regulation of cell cycle G1/S phase transition |
| positive regulation of binding |
| regulation of mRNA stability |
| regulation of RNA stability |
| nuclear-transcribed mRNA catabolic process |
| regulation of mRNA catabolic process |
| negative regulation of neuron death |
| mRNA catabolic process |
| regulation of synapse organization |
| regulation of synapse structure or activity |
| cellular response to nutrient levels |
| RNA catabolic process |
| positive regulation of protein complex assembly |
| negative regulation of cellular catabolic process |
| positive regulation of growth |
| cellular response to extracellular stimulus |
| positive regulation of cell cycle process |
| negative regulation of catabolic process |
| regulation of neuron death |
| multicellular organismal homeostasis |
| regulation of mRNA metabolic process |
| regulation of autophagy |
| cellular response to external stimulus |
| regulation of translation |
| positive regulation of neuron differentiation |
| nucleobase-containing compound catabolic process |
| positive regulation of cell cycle |
| regulation of binding |
| translation |
| regulation of cellular amide metabolic process |
| negative regulation of protein phosphorylation |
| peptide biosynthetic process |
| regulation of mitotic cell cycle phase transition |
| regulation of cell growth |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| mitochondrion organization |
| aromatic compound catabolic process |
| negative regulation of phosphorylation |
| regulation of cell cycle phase transition |
| regulation of protein complex assembly |
| positive regulation of neurogenesis |
| organic cyclic compound catabolic process |
| response to nutrient levels |
| positive regulation of cellular component biogenesis |
| posttranscriptional regulation of gene expression |
| amide biosynthetic process |
| peptide metabolic process |
| response to extracellular stimulus |
| positive regulation of nervous system development |
| positive regulation of cell development |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| behavior |
| negative regulation of protein modification process |
| regulation of mitotic cell cycle |
| regulation of neuron differentiation |
| regulation of growth |
| mRNA metabolic process |
| positive regulation of cell death |
| viral process |
| regulation of cellular response to stress |
| regulation of cell cycle process |
| symbiotic process |
| cellular amide metabolic process |
| regulation of neurogenesis |
| interspecies interaction between organisms |
| regulation of cellular catabolic process |
| cellular macromolecule catabolic process |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| negative regulation of cell death |
| regulation of catabolic process |
| positive regulation of protein phosphorylation |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| positive regulation of phosphorylation |
| identical protein binding |
| negative regulation of protein metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| defense response |
| positive regulation of developmental process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| ATP binding |
| generation of neurons |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| RNA metabolic process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 114/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 4/28 |
| blood | 3/28 |
| bone | 9/26 |
| breast | 6/33 |
| central nervous system | 10/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 4/21 |
| liver | 4/20 |
| lung | 10/75 |
| lymphocyte | 1/16 |
| ovary | 4/26 |
| pancreas | 2/24 |
| peripheral nervous system | 4/16 |
| plasma cell | 4/15 |
| prostate | 1/1 |
| skin | 3/24 |
| soft tissue | 2/9 |
| thyroid | 2/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 7/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 1449
- Expression level (log2 read counts): 9.64
Expression Distribution
EIF4G1 Expression in NALM6 Cells: 9.64
